Desogestrel versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation

Laganà, Antonio Simone; Palmara, Vittorio; Ciancimino, Leonarda; Chiofalo, Benito; Triolo, Onofrio

doi:10.3109/09513590.2014.929658

Cited by 23 publications

(16 citation statements)

References 22 publications

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“…To date, hysteroscopy represents a widely accepted method for the management of several gynecological conditions [ 16 – 20 ] or even to confirm ultrasound findings [ 21 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Cesarean Scar Pregnancy: A Single-Institution Retrospective Review

Giampaolino

Rosa

Morra

et al. 2018

BioMed Research International

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Objective Cesarean scar pregnancy (CSP) is a rare condition that occurs when the pregnancy implants in a cesarean scar. An early diagnosis and a proper management are fundamental to prevent maternal complications. We review and discuss the different treatment employed in our unit to reduce morbidity, preserve fertility, and predict possible complications. Methods The reported treatment has been expectant management, operative hysteroscopy approach, and intramuscular injection of 50 mg methotrexate (MTX), followed by cervical dilation and manual vacuum aspiration (D&S) with a Karman cannula under ultrasound guidance, uterine artery embolization (UAE), and manual vacuum aspiration under ultrasound guidance and uterine artery embolization before surgical laparotomic resection. Results Complications were more frequent in women with a history of three or more cesarean section deliveries and with a myometrial thickness thinner than 2 mm. MTX and D&S treatment appear to be most effective and safe at the early age of pregnancy, while UAE and D&S are related to the highest risk of complication in any age of pregnancy. Conclusion An appropriate preoperative diagnostic evaluation, the identification of cases at higher risk, and those eligible for a conservative treatment are fundamental to reduce complications.

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“…To date, hysteroscopy represents a widely accepted method for the management of several gynecological conditions [ 16 – 20 ] or even to confirm ultrasound findings [ 21 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Cesarean Scar Pregnancy: A Single-Institution Retrospective Review

Giampaolino

Rosa

Morra

et al. 2018

BioMed Research International

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“…Lagana et al 112 reported on a comparative study of desogestrel and danazol as a preoperative endometrial preparation for hysteroscopic surgery. Their observations were that desogestrel caused less side effects and presented obvious outcomes in inducing endometrial atrophy, this allowed for a better intraoperative management and was shown to cause less side effects during treatment.…”

Section: Conservative Non-surgical Treatmentmentioning

confidence: 99%

Endometrial polyps: Pathogenesis, sequelae and treatment

et al. 2019

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Endometrial polyps are overgrowths of endometrial glands that typically protrude into the uterine cavity. Endometrial polyps are benign in nature and affect both reproductive age and postmenopausal women. Although endometrial polyps are relatively common and may be accompanied by abnormally heavy bleeding at menstruation. In asymptomatic women, endometrial polyps may regress spontaneously, in symptomatic women endometrial polyps can be treated safely and efficiently with hysteroscopic excision.

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“…They did two randomized controlled trials comparing cervical dilatation with laminaria (25.9 ± 5.8 mm) which was less than vaginal and greater than oral misoprostol but the difference was not significant 21,25 . The current study focused on cervical priming methods, however, recent literature described several hormonal methods such as desogestrel to optimize the outcome of this surgery in terms of endometrial visibility, operating time and the occurrence of complications 26–28 …”

Section: Discussionmentioning

confidence: 85%

A comparative clinical trial of vaginal misoprostol versus intracervical normal saline infiltration as a cervical ripening agent at time of hysteroscopy

Hameed¹,

Farhan²

2020

J of Obstet and Gynaecol

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Cervical status has a great impact on the duration and success of its dilatation especially during hysteroscopy, so cervical ripening employed before the procedure can increase the success rate and minimize the complications. Aim To compare the efficacy of vaginal misoprostol and intracervical normal saline infiltration as cervical ripening agents. Methods A randomized comparative clinical trial had been conducted in AL Yarmouk Teaching Hospital involving two methods for cervical ripening before the hysteroscopic procedure. One Hundred women were enrolled in the study, fifty of them were those who used preoperative vaginal misoprostol and the other fifty patients were those who had been submitted to intracervical normal saline infiltration during surgery. Basal cervical dilatation, time to achieve 8 mm cervical dilatation, difficulties, and complications encountered during the procedure were evaluated and compared for both groups. Results The participants had been admitted for hysteroscopy for the following indications: Abnormal uterine bleeding, missed loop, infertility, polypectomy, endometrial resection, and myomectomy. Regarding operative findings, the basal cervical dilatation was not significantly different between them, the time required to achieve the required dilatation was significantly shorter for the normal saline infiltration group, 66.95 sec. ± 10.85 than for the misoprostol group which was 87.9 sec. ± 13.11. There was more difficulty in dilatation with more complications in the misoprostol group than in the normal saline infiltration group. Conclusions Normal saline infiltration is a simple, readily available at the time of surgery and with fewer complications and shorter time of dilatation in comparison to vaginal misoprostol for a comparable efficacy.

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Desogestrel versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation

Cited by 23 publications

References 22 publications

Management of Cesarean Scar Pregnancy: A Single-Institution Retrospective Review

Management of Cesarean Scar Pregnancy: A Single-Institution Retrospective Review

Endometrial polyps: Pathogenesis, sequelae and treatment

A comparative clinical trial of vaginal misoprostol versus intracervical normal saline infiltration as a cervical ripening agent at time of hysteroscopy

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