Desmutagenic effect of humic acid

Sato, Takahiko; Ose, Youki; Nagase, Hisamitsu

doi:10.1016/0027-5107(86)90083-7

Cited by 37 publications

(27 citation statements)

References 8 publications

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“…Ž As observed previously by other authors De Marco . et al, 1999;Sato et al, 1986 , treatments with soil HA or soil FA and leonardite HA do not increase the percentages of MN and aberrant AT with respect to the control, whereas an evident decrease of the number of cells in mitotic division is observed for the treatments with soil HA and soil FA, but not with leonardite HA. As expected, the MH treatment causes a marked increase of both MN and aberrant AT frequencies and strongly inhibits cell division.…”

Section: Resultsmentioning

confidence: 99%

“…shaking for 24 h at room temperature 20 " 2ЊC before w addition to the seeds procedure 1, in which the seeds were germinated in the presence of interacted humic substances and MH in order to test the possible desmutagenic activity of HA andror FA, according to Ž .x Ž . Sato et al 1986 ; and e soil HA or soil FA alone at two concentrations for a period of 6 days, then added with 4 mL of 10 mg L y1 MH for the following 24 h, w after transfer of the seeds procedure 2, in which no interaction was allowed between soil HA or soil FA and MH in the germination medium, used with the purpose of excluding the desmutagenic action and testing the possible antimutagenic behavior, according to Ž .…”

Section: Methodsmentioning

confidence: 99%

“…x Sato et al 1986 . In the latter procedure the control seeds were treated with H O for 6 days and then with 4 2 mL of a 10 mg L y1 MH solution for 24 h. All the experiments were triplicated.…”

Section: Methodsmentioning

confidence: 99%

“…These include the Ames test, the sister᎐chromatid exchange induction, and the counting of the number of micronuclei and aberrant cell divi-Ž sions Chand at al., 1991;Cozzi et al, 1993;De Marco . et al, 1995;Sato et al, 1986 . Mutagenic effects of humic substances have been Ž reported on a wide variety of cells Bernacchi et al, . 1996;Nunn and Chipman, 1994;Ribas et al, 1997 . Further, humic substances, which are the predominant organic species present in waters used for drinking supplies, have been found to be the precursors of many mutagenic and carcinogenic compounds formed in Ž chlorinated and ozonated drinking waters Holmbom et .…”

mentioning

confidence: 99%

“…1986 . In particular, Sato et al 1986 reported a marked desmutagenic effect of HA isolated from wood leaf mould on Salmonella typhimurium grown in the presw x ence of benzo a pyrene. Seedlings of Vicia faba, treated with various herbicides, showed a reduced number of genetic anomalies when they were grown in an organic Ž soil with respect to a sandy soil De .…”

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confidence: 99%

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Evaluation of antimutagenic and desmutagenic effects of humic and fulvic acids on root tips ofVicia faba

et al. 2000

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Humic acids HA and fulvic acids FA of different origin were evaluated for their antimutagenic and/ or desmutagenic activity on Vicia faba germinating seeds treated with the mutagen ( ) compound maleic hydrazide MH . Both HA and FA were tested at two different concentrations, 20 and 200 mg L y1 , either alone or together with 10 mg L y1 of MH. Two experimental procedures were used to investigate the occurrence and nature of the antimutagenic or desmutagenic activity. In procedure 1, HA or FA and MH were interacted for 24 h and then added to the seeds. In procedure 2, the seeds were first treated with HA or FA for 6 days and then transferred to plates containing the MH solution, so that no interaction occurred between HA or FA and MH outside the seeds. The evaluation of the genotoxic activity was done by counting both micronuclei and aberrant anatelophases in root tip cells. Results obtained by using procedure 1 showed a clear desmutagenic action of HA and FA used at both concentrations, whereas results of procedure 2 indicated no antimutagenic effect of HA or FA. ᮊ 2000 by John Wiley & Sons, Inc. Environ Toxicol 15: 513᎐517, 2000

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Evaluation of antimutagenic and desmutagenic effects of humic and fulvic acids on root tips ofVicia faba

et al. 2000

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Genotoxicity of humic acid in cultured human lymphocytes and its interaction with the herbicides alachlor and maleic hydrazide

Ribas

Carbonell

Creus

et al. 1997

Environ. Mol. Mutagen.

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Graphene oxide as a scaffold for bone regeneration

Holt

Wright

Arnold

et al. 2016

WIREs Nanomed Nanobiotechnol

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Graphene oxide (GO), the oxidized form of graphene, holds great potential as a component of biomedical devices, deriving utility from its ability to support a broad range of chemical functionalities and its exceptional mechanical, electronic, and thermal properties. GO composites can be tuned chemically to be biomimetic, and mechanically to be stiff yet strong. These unique properties make GO-based materials promising candidates as a scaffold for bone regeneration. However, questions still exist as to the compatibility and long-term toxicity of nanocarbon materials. Unlike other nanocarbons, GO is meta-stable, water dispersible, and autodegrades in water on the timescale of months to humic acid-like materials, the degradation products of all organic matter. Thus, GO offers better prospects for biological compatibility over other nanocarbons. Recently, many publications have demonstrated enhanced osteogenic performance of GO-containing composites. Ongoing work toward surface modification or coating strategies could be useful to minimize the inflammatory response and improve compatibility of GO as a component of medical devices. Furthermore, biomimetic modifications could offer mechanical and chemical environments that encourage osteogenesis. So long as care is given to assure their safety, GO-based materials may be poised to become the next generation scaffold for bone regeneration. WIREs Nanomed Nanobiotechnol 2017, 9:e1437. doi: 10.1002/wnan.1437 For further resources related to this article, please visit the WIREs website.

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Desmutagenic effect of humic acid

Cited by 37 publications

References 8 publications

Evaluation of antimutagenic and desmutagenic effects of humic and fulvic acids on root tips ofVicia faba

Evaluation of antimutagenic and desmutagenic effects of humic and fulvic acids on root tips ofVicia faba

Genotoxicity of humic acid in cultured human lymphocytes and its interaction with the herbicides alachlor and maleic hydrazide

Graphene oxide as a scaffold for bone regeneration

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