Desmoschinensisflavones A and B, two rare flavones having a hybrid benzyl benzoate ester-flavone structural framework from <i>Desmos chinensis</i> Lour

Polbuppha, Isaraporn; Suthiphasilp, Virayu; Maneerat, Tharakorn; Charoensup, Rawiwan; Limtharakul, Thunwadee; Cheenpracha, Sarot; Pyne, Stephen G.; Laphookhieo, Surat

doi:10.1039/d0ra09985f

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In the anticancer flavone-estradiol merged hybrids (60), there is a common aromatic A-rin of the flavone and the steroid in the molecule [35]. Desmoschinensisflavones A and B having a flavonebenzylbenzoate hybrid structural framework, were isolated from Desmo chinensis Lour [74]. Some interesting flavone esters are also known; quercetin was esteri fied with aspirin in position 7 [75] and showed moderate anticancer activities, while chry sin was coupled with linolenic and linoleic acid on 7-OH [76], showing a competitive in hibitory effect on mushroom tyrosinase activity.…”

Section: Miscellaneousmentioning

confidence: 99%

Flavone Hybrids and Derivatives as Bioactive Agents

Hazai,

Zsoldos,

Halmai

et al. 2024

Applied Sciences

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Hybrid molecules can be defined as chemical entities with two or more structural domains, namely pharmacophores, having a specific biological effect. In many cases, when at least one of the components is biologically inactive, it is rather correct to call them “derivatives”, despite the fact that in the literature they are often mentioned also as hybrids. We have summarized such types of molecules, in which one of the components is mostly a real pharmacophore, i.e., flavone, which is one of the best-known natural bioactive substances. Structures, synthetic methods, medicinal indications, and more important activity data are presented.

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