1977
DOI: 10.1002/1097-0142(197712)40:6<2979::aid-cncr2820400633>3.0.co;2-8
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Desmoplastic trichoepithelioma

Abstract: Fifty examples of a distinctive clinicopathologic entity occurred in 49 patients who ranged in age from 8 to 70 (median 46) years. Forty-nine tumors were on the face, mainly the cheek, chin and forehead; most were present one to five years, and 85% of the patients were female. The growths varied in size from 3 to 8 mm; many were hard and annular, with a raised border and depressed nonulcerated center. Histologically, narrow strands of basaloid cells and epidermoid cyts infiltrated a fibrotic stroma. This tumor… Show more

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Cited by 128 publications
(102 citation statements)
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“…[1][2][3] Desmoplastic trichoepithelioma is an uncommon benign neoplasm of follicular derivation that usually manifests as a sporadic asymptomatic small indurated annular lesion with a raised border and a depressed center over the face of adolescents and young adults. [3][4][5][6] Like morpheaform/infiltrative basal cell carcinoma, desmoplastic trichoepithelioma is characterized by infiltrating strands and islands of monomorphic, basaloid cells with scant cytoplasm and prominent oval nuclei embedded in a sclerotic and hypocellular stroma. [3][4][5][6] Features of use in distinguishing desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma include the additional presence of variably sized horn cysts and foreign-body granulomas in the former.…”
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confidence: 99%
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“…[1][2][3] Desmoplastic trichoepithelioma is an uncommon benign neoplasm of follicular derivation that usually manifests as a sporadic asymptomatic small indurated annular lesion with a raised border and a depressed center over the face of adolescents and young adults. [3][4][5][6] Like morpheaform/infiltrative basal cell carcinoma, desmoplastic trichoepithelioma is characterized by infiltrating strands and islands of monomorphic, basaloid cells with scant cytoplasm and prominent oval nuclei embedded in a sclerotic and hypocellular stroma. [3][4][5][6] Features of use in distinguishing desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma include the additional presence of variably sized horn cysts and foreign-body granulomas in the former.…”
mentioning
confidence: 99%
“…[3][4][5][6] Like morpheaform/infiltrative basal cell carcinoma, desmoplastic trichoepithelioma is characterized by infiltrating strands and islands of monomorphic, basaloid cells with scant cytoplasm and prominent oval nuclei embedded in a sclerotic and hypocellular stroma. [3][4][5][6] Features of use in distinguishing desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma include the additional presence of variably sized horn cysts and foreign-body granulomas in the former. [3][4][5][6] Although desmoplastic trichoepithelioma is a benign tumor that can be managed by conservative treatment such as curettage or shave biopsy, morpheaform/infiltrative basal cell carcinoma is an aggressive malignant neoplasm that requires complete excision usually with Mohs micrographic surgery.…”
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confidence: 99%
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“…The desmoplastic trichoepithelioma typically presents as a small mid-facial papule or as multiple small firm papules as distinct from the ill-defined plaque of microcystic adnexal carcinoma. 218,231,232 This clinical morphology has a histologic analog; in particular, the microcystic adnexal carcinoma is widely invasive to the edges of a 5-mm punch biopsy specimen, whereas the desmoplastic trichoepithelioma might well be completely encompassed by a biopsy of this size. Put another way, the desmoplastic trichoepithelioma is a shallow tumor, whereas the microcystic adnexal carcinoma invades deeply.…”
Section: Differential Diagnosismentioning
confidence: 99%