Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis

Darwish, Basma; Arbuckle, Susan; Kellie, Stewart J.; Besser, Michael; Chaseling, Raymond

doi:10.1016/j.jocn.2006.01.024

Cited by 47 publications

(46 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, LC is an important endpoint, because recurrent gangliogliomas may have a malignant course, including craniospinal dissemination, or may cause neurologic symptoms (such as seizures) or intracerebral hemorrhage. 45,79,98,133,134,[147][148][149] In addition, locally recurrent tumors may require repeat craniotomies, which carry additional risks. Furthermore, anaplastic astrocytoma or even glioblastoma multiforme may develop at the time of recurrence.…”

Section: Discussionmentioning

confidence: 99%

The role of postoperative radiotherapy for the treatment of gangliogliomas

Rades

Zwick

Leppert

et al. 2009

Cancer

View full text Add to dashboard Cite

BACKGROUND: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma. METHODS: In 402 patients with ganglioglioma, outcomes were compared for patients who underwent gross total resection alone (GTR) (n ¼ 188), GTR plus radiotherapy (GTR þ RT) (n ¼ 21), subtotal resection alone (STR) (n ¼ 113), and STR plus RT (STR þ RT (n ¼ 80). Age, sex, tumor site, and histologic grade also were investigated. Subgroup analyses were performed for both low-grade and high-grade tumors. RESULTS: The 10-year LC rates were 89% after GTR, 90% after GTR þ RT, 52% after STR, and 65% after STR þ RT (P < .001); and the 10-year OS rates were 95%, 95%, 62%, and 74%, respectively (P < .001). After STR, irradiation significantly improved LC (P ¼ .004) but not OS (P ¼ .22). After GTR, irradiation did not significantly improve LC (P ¼ .23) or OS (P ¼ .29). On multivariate analyses, LC and OS were associated with therapy and pathologic grade, and OS also was associated with tumor site. In low-grade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .18); and, after GTR, LC (P ¼ .28) and OS (P ¼ 1.0) were not improved with postoperative radiotherapy. In highgrade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .41); after GTR, LC (P ¼ .56) and OS (P ¼ .61) were not improved with irradiation. CONCLUSIONS: According to this review, GTR should be performed whenever safely possible and does not require postoperative irradiation. If only STR is achieved, then RT improves LC of both low-grade and high-grade tumors and, thus, should be considered seriously. Cancer 2010;116:432-42.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of postoperative radiotherapy for the treatment of gangliogliomas

Rades

Zwick

Leppert

et al. 2009

Cancer

View full text Add to dashboard Cite

show abstract

“…These tumors usually occur in infants aged between 1 and 24 months with a male/female ratio of 1.7/1.0 [4]. Radiologically, they may manifest as large cystic and solid well-defined supratentorial lesions that involve the cerebral cortex and leptomeninges, attached to the dura mater [19].…”

Section: Introductionmentioning

confidence: 99%

“…Radiologically, they may manifest as large cystic and solid well-defined supratentorial lesions that involve the cerebral cortex and leptomeninges, attached to the dura mater [19]. Two histologic forms, which were integrated in the same tumor class according to the World Health Organization classification, have been described: desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) [4,19]. The presence of a neuronal component in DIG is the only difference between both subtypes [4].…”

Section: Introductionmentioning

confidence: 99%

Desmoplastic infantile astrocytoma with multiple intracranial and intraspinal localizations at presentation

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4]9,11,14,15,19,20,22,23,27,30,[37][38][39][40]43,44 A homogeneously and avidly enhancing solid nodule was the most common finding among those cases (27 of 32). 1,3,4,9,11,14,15,19,22,27,30,[38][39][40]43 Either no contrast was given or the pattern of enhancement was interpreted as heterogeneous in 7 cases. 2,15,20,23,37,44 Only 1 publication reported the features of DIG on DWI; 37 however, the description was vague.…”

Section: Resultsmentioning

confidence: 99%

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

View full text Add to dashboard Cite

OBJECT Two of the more common infantile brain tumors, glioblastoma multiforme (GBM) and desmoplastic infantile tumors (DITs), can be difficult to distinguish on MRI. Both tumors occur in the supratentorial compartment and both have solid and cystic components. Differentiating between the 2 on MRI studies could assist the surgeon in discussions with family and child management. The authors report on their institutional experience with both tumors, focusing on radio-graphic features, especially the diffusion studies, which might be useful in distinguishing between infantile GBM and DIT. METHODS A retrospective review was undertaken of all infantile brain tumors treated at British Columbia’s Children’s Hospital between 1982 and 2012, and cases of GBM and DIT were recorded. Only cases that had imaging were included in the study. A literature review was completed to identify reported cases of infantile GBM and DIT. Only reports that described or included radiological studies (particularly MRI) of the tumors were included. Certain radiographic features of the tumors were reviewed, including location, size, consistency, pattern of enhancement, and features on MR diffusion studies. RESULTS Of 70 cases of infantile brain tumors, 2 GBM cases and 3 DIT cases (all 3 of which were desmoplastic infantile gangliogliomas [DIGs]) met the inclusion criteria. The radiological studies obtained in all 5 cases were reviewed by a neuroradiologist. All 5 patients had supratentorial tumors with cystic-solid consistency. Diffusion MRI studies showed restricted diffusion in the 2 GBM cases, but no evidence of restricted diffusion in the DIG tumors. The GBM tumors were heterogeneously enhancing, and the DIG tumors showed avid and homogeneous enhancement. The literature review revealed 29 cases of infantile GBM and 32 cases of DIG/DIT that met the inclusion criteria. The tumors were large in both groups. The tumors were cystic-solid in consistency in 10 of 30 (33%) of GBM cases and 28 of 32 (87.5%) of DIT cases. The contrast enhancement was heterogeneous in 9 of 30 (30%) GBM cases, and it was homogeneous and avid in 27 of 32 (84%) of DIT cases. Diffusion studies were recorded in 2 published infantile GBM cases, and in both of them diffusion was restricted. The authors only found 1 report that discussed DIG tumor features on MR diffusion studies, but the interpretation was difficult and unclear. CONCLUSIONS Magnetic resonance imaging, especially diffusion-weighted imaging, may be a useful aid in distinguishing between infantile GBM and DIT tumors, with infantile GBM demonstrating restricted diffusion.

show abstract

Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis

Cited by 47 publications

References 5 publications

The role of postoperative radiotherapy for the treatment of gangliogliomas

The role of postoperative radiotherapy for the treatment of gangliogliomas

Desmoplastic infantile astrocytoma with multiple intracranial and intraspinal localizations at presentation

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Contact Info

Product

Resources

About