Desmoplastic Fibroma Arising From the Anterior Maxillary Sinus in a Child

Azola, Alba; Wartmann, Christopher T.; Fischer, Max; Ambro, Bryan T.; Pereira, Kevin D.

doi:10.1001/archoto.2012.1661

Cited by 9 publications

(10 citation statements)

References 6 publications

(11 reference statements)

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“…In 2005, Hauben et al [10] reported two cases of mandibular DFs that stained positively with b-catenin; however only one demonstrated nuclear positivity and thereby deemed true positive labeling. Multiple cases of gnathic DF have since been shown to be reactive to b-catenin [10,17,18]. Most recently, Gondak et al [19] reported a maxillary lesion with negative reactivity to b-catenin (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature

Woods

Cohen

Islam

et al. 2014

Head and Neck Pathol

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The desmoplastic fibroma (DF) is a rare, fibroblastic lesion of bone that histologically resembles the desmoid tumor of soft tissue. Although classified as benign, it frequently demonstrates aggressive behavior, often causing tooth mobility, extensive bone destruction, and has a moderate to high recurrence rate. We present three cases of DF in the mandible: the first in a 13 year old female involving the mandibular body in the region of teeth #s 27-#28, the second in a 57 year old female with a lesion apical to tooth #30, and the third in a 20-year-old female involving the left posterior mandible. Clinical, histologic, immunohistochemical (IHC) and radiographic features of this rare neoplasm are discussed. The challenges encountered in establishing an accurate diagnosis due to significant microscopic overlap with other spindle cell lesions are also detailed. Additionally, the findings of IHC stains including vimentin, smooth muscle actin, S-100 protein, bcatenin, HHF-35 and proliferation marker, Ki-67 on 3 cases are reported. The potential for misdiagnosis is high, especially in early lesions, since immunohistochemistry has been reported in literature to be inconsistent when differentiating DFs from other spindle cell lesions. A comparative review of DF and similar entities in the jaws with current considerations in treatment and prognosis is presented.

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Section: Discussionmentioning

confidence: 99%

Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature

Woods

Cohen

Islam

et al. 2014

Head and Neck Pathol

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“…Bony involvement is typically rare, but according to Azola et al, 30% of patient may have cortical destruction on imaging similar to that seen in osteosarcoma [9].…”

Section: Literature Review and Discussionmentioning

confidence: 96%

“…Prior to 2001, only 40 cases of DF arising from the maxillary sinus were reported [3]. Prior to 2012, only 75 cases of desmoplastic fibroma in the gnathic skeleton have been reported in total [9]. Of note, there has been one reported case of DF afflicting the vidian canal [10].…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…Histologic analysis of DF shows a lesion composed of spindle cells with elongated nuclei and eosinophilic cytoplasm embedded in a dense collagenous matrix. There are usually no mitotic figures present and atypia is rarely seen [9,11]. Immunohistochemical staining is of limited value.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…A study done by Said-al-Naief in 2006 showed that there was a 0% recurrence with wide local excision, whereas curettage alone led to 70% recurrence followed by 20-40% recurrence with simple enucleation [13]. In two separate studies of patients with maxillary sinus DF, wide local excision via maxillectomy approach resulted in complete tumor resection and no recurrence with long term follow up [3,9]. Some have advocated post-operative chemotherapy with Adriamycin, but side effects of cardiotoxicity make this option less favorable in the pediatric population; it is often reserved for those who have contraindications to surgical therapy [12].…”

Section: Literature Review and Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric ethmoid sinus desmoplastic fibroma: Case report and review of pediatric bony sinus tumors

Kadakia

Patel

Iacob

et al. 2015

International Journal of Pediatric Otorhinolaryngology Extra

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Desmoplastic fibroma of the jaw bones: A series of twenty-two cases

Kahraman

Karakoyunlu

Karagece³

et al. 2021

Journal of Bone Oncology

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Highlights In desmoid-type soft tissue fibromatosis we could see the beta-catenin in the nuclei of neoplastic cells as a diagnostic feature. Beta-catenin in the nuclei of neoplastic cells could not be detected in the present DF series. Most of the DF cases expressed only cytoplasmic beta-catenin immunostainings. Immunohistochemical staining difference of jaw bone desmoplastic fibromas from other soft tissue and bone lesions may be related to the origination of jaw bone from the neural crest.

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Desmoplastic Fibroma Arising From the Anterior Maxillary Sinus in a Child

Cited by 9 publications

References 6 publications

Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature

Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature

Pediatric ethmoid sinus desmoplastic fibroma: Case report and review of pediatric bony sinus tumors

Desmoplastic fibroma of the jaw bones: A series of twenty-two cases

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