Desmoid tumors: A novel approach for local control

Baliski, Christopher; Temple, Walley J.; Arthur, Keith; Schachar, Norman S.

doi:10.1002/jso.10104

Cited by 50 publications

(36 citation statements)

References 17 publications

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“…Traditionally, desmoid tumours have been managed with surgery with wide local excision being the preferred treatment [3,10,16,19]. Over the past 10 years, adjuvant therapy, employing radiation therapy, chemotherapy, anti-estrogenic agents such as tamoxifen and even NSAIDs have been used in an attempt to reduce the risk of local recurrence [1,11,14]. Despite various studies, the natural history of these tumours remains enigmatic, with paucity of information on the optimal treatment protocol.…”

Section: Introductionmentioning

confidence: 99%

The management of extra-abdominal desmoid tumours

Duggal

Dickinson

Sommerville

et al. 2004

International Orthopaedics (SICOT)

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We performed a retrospective analysis of 35 cases of desmoid tumours (aggressive fibromatoses) that underwent treatment at our institutions between 1987 and 2002. The purpose was to evaluate the rate of local recurrence of desmoid tumours treated with surgical excision, to assess the impact of surgical margins on local recurrence and to define the role of radiotherapy in the treatment. Nine patients experienced a recurrence at an average of 16 months after initial treatment. Seven of the 15 patients with a less-than-wide margin had a local recurrence. Comparatively, only two of the 20 patients with a wide margin had a local recurrence. Thirty-three of the 35 patients were disease free at the last follow-up. We recommend wide excision with clear margins whenever possible. Marginal resections are appropriate when wide excision would severely compromise the function of the limb. Surgical resections and selective supplementation of adjuvant radiotherapy give excellent control rates.Résumé Nous avons exécuté une analyse rétrospective de 35 cas de tumeurs desmoides (fibromatose agressive) traitées dans notre institution entre 1987 et 2002. Le but était d'évaluer le taux de récidive locale après traitement par excision chirurgicale, d'étudier le rôle des marges chirurgicales sur la récidive et de définir le rôle de la radiothérapie dans le traitement. Neuf malades ont eu une récidive à une moyenne de 16 mois après le traitement initial. Sept des 15 malades opérés avec une marge qui n'était pas large, avait une récidive locale. Comparativement, seulement 2 des 20 malades avec une marge large avaient une récidive locale. Trente trois des 35 malades étaient sans maladie au dernier suivi. Nous recommandons l'excision large avec des marges claires toutes les fois que possible. Les résections marginales sont appropriées quand l'excision large compromettrait sévèrement la fonction du membre. Les résections chirurgicales avec, sélectivement, un traitement adjuvant par radiothérapie donnent d'excellents taux de contrôle de la maladie.

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Section: Introductionmentioning

confidence: 99%

The management of extra-abdominal desmoid tumours

Duggal

Dickinson

Sommerville

et al. 2004

International Orthopaedics (SICOT)

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“…Five year local recurence rates of 8 to 44% were reported by other series, and was 36% in the present study (2,34,110,114,115,137,182,184). Most recurrences are usually observed within 3 years, and nearly all by 6 years and m ost of the studies found that the presence of positive surgical margin proved to be relevant in patients with recurrent disease (19,34,110,114,115,137,(182)(183)(184). Well corresponding with these results, the median time to recurrence in our series was 26 months (range 6-110 months) and the investigator established that obtaining a wide disease-free margin is crucial for reducing the recurrence rate.…”

Section: Sporadical Desmoid Tumors Of the Abdominal Wallsupporting

confidence: 66%

“…Due to the lack of randomized, controlled trials, we have tried to extrapolate from the published series those cases with tumors localized to the abdominal wall to compare with our findings (2,19,34,110,114,115,137,(182)(183)(184). Table 22.…”

Section: Sporadical Desmoid Tumors Of the Abdominal Wallmentioning

confidence: 95%

Diagnosis and multidisciplinary treatment of sporadical desmoid tumors

Mátrai¹

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“…A Tri-Center Study confirmed local control rates of 98.5% [6]. Furthermore, the same approach to desmoid tumors yields an 85% 5-year local control rate [7]. This is despite desmoid tumors having notoriously high local recurrence rates ranging from 18 to 56% [8][9][10].…”

Section: Discussionmentioning

confidence: 93%