The present study provides statistically significant evidence that increasing the width of resection improves local control and overall survival.
We performed a retrospective analysis of 35 cases of desmoid tumours (aggressive fibromatoses) that underwent treatment at our institutions between 1987 and 2002. The purpose was to evaluate the rate of local recurrence of desmoid tumours treated with surgical excision, to assess the impact of surgical margins on local recurrence and to define the role of radiotherapy in the treatment. Nine patients experienced a recurrence at an average of 16 months after initial treatment. Seven of the 15 patients with a less-than-wide margin had a local recurrence. Comparatively, only two of the 20 patients with a wide margin had a local recurrence. Thirty-three of the 35 patients were disease free at the last follow-up. We recommend wide excision with clear margins whenever possible. Marginal resections are appropriate when wide excision would severely compromise the function of the limb. Surgical resections and selective supplementation of adjuvant radiotherapy give excellent control rates.Résumé Nous avons exécuté une analyse rétrospective de 35 cas de tumeurs desmoides (fibromatose agressive) traitées dans notre institution entre 1987 et 2002. Le but était d'évaluer le taux de récidive locale après traitement par excision chirurgicale, d'étudier le rôle des marges chirurgicales sur la récidive et de définir le rôle de la radiothérapie dans le traitement. Neuf malades ont eu une récidive à une moyenne de 16 mois après le traitement initial. Sept des 15 malades opérés avec une marge qui n'était pas large, avait une récidive locale. Comparativement, seulement 2 des 20 malades avec une marge large avaient une récidive locale. Trente trois des 35 malades étaient sans maladie au dernier suivi. Nous recommandons l'excision large avec des marges claires toutes les fois que possible. Les résections marginales sont appropriées quand l'excision large compromettrait sévèrement la fonction du membre. Les résections chirurgicales avec, sélectivement, un traitement adjuvant par radiothérapie donnent d'excellents taux de contrôle de la maladie.
Persistency is the time from initiation to discontinuation of therapy. Previous research has described factors that affect the persistency of initial antiretroviral therapy (ART); however, the impact of persistency on clinical outcomes is unknown. A retrospective study was conducted of treatment-naive HIV patients initiating ART between January 1, 2000 and December 31, 2010 at an academic medical center. Descriptive statistics and Cox proportional hazards regression models with persistency as a time-varying covariate were fit for (1) immunologic failure (subsequent CD4 lower than initial CD4); (2) development of an opportunistic infection (OI) or malignancy; and (3) mortality. Analyses were repeated with an interaction term of persistency (per 180 days) and time (before and after 1 year of ART). Among 879 patients who started ART, the mean age was 38 years ( -10) and most patients were racial/ethnic minority (59%), males (80%), and with baseline CD4 < 200 cells/mm 3 (52%). There were 100 deaths, 94 OIs/malignancy, and 183 immunologic failures; the mean persistency = 723 days. In multivariable modeling, increased persistency decreased the overall and long-term hazard for immunologic failure (0.84 per 180 additional days; 0.70-1.00; 0.045). Increased persistency exhibited a potential trend toward decreased hazard for the occurrence of OI/malignancy (0.91; 0.80-1.03; 0.124) overall and after 1 year. Persistency exhibited a trend toward less risk of mortality in the first year of ART (0.42; 0.067). In this study of the relationship between initial ART persistency and clinical outcomes, increased persistency was associated with a decreased hazard for the development of immunologic failure, a trend toward a decreased hazard for OI/ malignancy, and a trend toward a decreased risk of first year mortality. Given these findings, the relationship between persistency and clinical outcomes merits further study.
Wire ropes are considered and applied to industrial applications that includes mining, off-shore oil production, and towing or mooring ships. Wire ropes are also used extensively in such diverse transportation applications as ski-lifts, cable cars, bridges, cranes and elevators. Premature failure of ropes can be costly in any application. In mining, the human costs due to the premature failure of a rope can be devastating. The wire rope considered in present research is IS 398, ACSR Conductor, Theoretical calculations are performed to calculate sag and slack for the rope. Distance between poles is taken as considered 30480mm. Thermal elongation with temperature variation is calculated and also simulated and analyzed with ANSYS design software. Aeolian vibration frequency is calculated to obtain frequencies with different wind speed, Software results for frequencies are found similar to theoretically calculated results. Experimental analysis is performed in IIT Indore to conduct tensile. It is found that breaking load is approximately 28KN and software simulation results for tensile test are approx. 30KN. Present research ultimately tried to focus on the modeling and analysis of wire rope for transmission lines considering the pole distance and sag of the wire rope, further comparing the simulated results with the theoretical, and trying to make a common set up for the test and validation of results experimentally.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.