Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double‐blind, placebo‐controlled study

Nettis, Eustachio; Colanardi, Maria Cristina; Paradiso, M. T.; Ferrannini, A.

doi:10.1111/j.1365-2222.2004.02019.x

Cited by 110 publications

(84 citation statements)

References 28 publications

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“…This hypothesis is consistent with patient response to other kinds of placebos in randomized trials of urticaria treatments. For example, de Silva and colleagues [27] identified five randomized trials of montelukast in which control patients received oral placebos [30][31][32][33][34]. The changes in symptom severity from baseline to the end of treatment in these studies ranged from a 36% average decrease to a 5% average increase (median = 8% decrease).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Brewer¹

2014

Cureus

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Brewer¹

2014

Cureus

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“…14,15,23,[28][29][30] However, in many studies, challenge with ASA 15,19,[22][23][24][25]28,29,31,32 and ⁄ or ASST 13,19,22,[24][25][26][27]31,32 have not been reported or performed. Finally, many patients were affected by physical urticaria.…”

Section: Discussionmentioning

confidence: 99%

“…35 Thus, the results of the controlled studies and clinical experience indicate that these agents are generally safe and well-tolerated, with an incidence of adverse effects generally comparable with placebo. [26][27][28][29][30][31][32][33] Learning points…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the combination of desloratadine plus montelukast was effective in the treatment of CU. 32 We have treated 160 patients affected by chronic idiopathic urticaria with montelukast alone or in combination with a nonsedating antihistamine (desloratadine), or only with nonsedating antihistamine, or with matched placebo. In this study.…”

Section: Controlled Studiesmentioning

confidence: 99%

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Is there a role for antileukotrienes in urticaria?

et al. 2006

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SummaryIn vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, i.e. leukotriene receptor antagonists and synthesis inhibitors, are a new class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma. We searched the MedLine database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin or food additive hypersensitivity or with autoreactivity to intradermal serum injection when taken with an antihistamine but not in moderate chronic idiopathic urticaria. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angio-oedema, and exerciseinduced anaphylaxis.

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“…One study compared the treatment of CIU with desloratadine alone and with desloratadine plus montelukast. According to study data, the combination of desloratadine plus montelukast was found to improve the symptoms and patient quality of life significantly more than desloratadine alone, although it did not have a significant effect on the number of urticarial episodes (57,83,84). Another comparative study of desloratadine alone, montelukast alone and a combination of these two drugs demonstrated desloratadine to be highly effective for the treatment of patients affected by CIU.…”

Section: Leukotriene Receptor Antagonistsmentioning

confidence: 99%

Treatment of Chronic Urticaria

Tončić

Lipozenčić²,

Marinović³

2009

Urticaria and Angioedema, Second Edition

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Summary Urticaria is a disorder characterized by rapid onset of localized swelling of the skin or mucosa, called wheals or urtica. According to frequency and duration, urticaria can be divided into acute and chronic type. Chronic urticaria is any type of urticaria occurring every day or twice per week, lasting longer than 6 weeks. Chronic urticaria is a common disorder and estimated prevalence is 1% of the population. Also, it is not rare in childhood. The pathogenesis of chronic urticaria has not yet been completely understood. Chronic urticaria is a heterogeneous group of disorders, and according to the etiology and cause, several groups of chronic urticaria are distinguished, i.e. autoimmune, pseudoallergic, infection-related, physical urticaria, vasculitis urticaria and idiopathic urticaria. Treatment and management of chronic urticaria can be non-pharmacological and pharmacological, and sometimes it is not possible to control the disease with antihistamines only, which are considered to be the mainstay of treatment. In severe cases of chronic urticaria, especially if autoimmunity has been proven, several authors describe different modules of immunomodulation: cyclosporine, cyclophosphamide, mycophenolate-mofetil, omalizumab, plasmapheresis, systemic corticosteroids, and immunoglobulin therapy. This article primarily addresses the treatment of chronic idiopathic and autoimmune urticaria.

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Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double‐blind, placebo‐controlled study

Abstract: The combination of desloratadine plus montelukast is effective in the treatment of CU. It may therefore be a valid alternative in patients with relatively mild CU, in view of its efficacy and the lack of adverse events.

Cited by 110 publications

References 28 publications

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Is there a role for antileukotrienes in urticaria?

Treatment of Chronic Urticaria

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