Desloratadine citrate disodium injection, a potent histamine H1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades

Chen, Mei‐Ling; Xu, Shuhong; Peipei, Zhou; He, Guangwei; Jie, Qiong; Wu, Yafang

doi:10.1016/j.ejphar.2015.10.014

Cited by 15 publications

(6 citation statements)

References 25 publications

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“…Desloratadine citrate disodium can specifically bind to the H1 receptor with high selectivity to relieve the symptoms associated with chronic urticaria, and it has the advantages of rapid oral absorption, short onset time, long half-life and less adverse reactions. 11,12 In this study, desloratadine citrate disodium was used for the treatment of chronic urticaria, and its effects on patients were observed from the aspects of immune parameters, inflammatory factors and chemokines. Urticaria belongs to the type I allergic reaction.…”

Section: Discussionmentioning

confidence: 99%

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

Wang

Zhao

Yan

2019

J Coll Physicians Surg Pak

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were selected as study subjects. Inclusion criteria were clinically diagnosed as chronic urticaria, with symptoms and signs of urticaria 24 hours before the experiment; and no other antihistamines, anticholinergic agents, receptor agonists, aspirin drugs or glucocorticoids taken within 2 weeks. Exclusion criteria were pregnant women, lactating women, women of childbearing age who planned to have children in the near future;

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Section: Discussionmentioning

confidence: 99%

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

Wang

Zhao

Yan

2019

J Coll Physicians Surg Pak

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“…The researchers used lidocaine inhalation anesthesia to prevent the antigen from being removed by nasal ciliary activity (11) . Chen et al (5) reported that AR was induced by IP injection of OVA on days 1, 3, 5, 7, 14 and 21, and then instillation of intranasal OVA for seven consecutive days.…”

Section: Discussionmentioning

confidence: 99%

“…Animal models of AR are extremely important for research studies on AR. To date, guinea pigs, mice, rats and rabbits have been used in animal models of AR (4)(5)(6)(7)(8) . Firstly, guinea pigs were used, and BALB/c type mice have been used mostly in recent years (4) .…”

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confidence: 99%

A New Experimental Allergic Rhinitis Model in Mice

Köse¹,

Kiş²,

Diniz³

et al. 2021

BUCH

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Objective: Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa mediated by IgE after exposure to an allergen. The most well known related comorbidity of AR is asthma. This study was planned due to the need for an animal model for studies on AR-asthma coexistence. In this study, the frequency of AR accompanying in the asthma model created in mice,and the usability of the related model in AR studies will be investigated. Methods: In our study, 6-8 week-old, 18-20 g BALB/c mice were used. Chicken egg ovalbumin (OVA Grade V, Sigma) was administered through intraperitoneal (IP) route at doses of 10 μg on days 0 and 14. Mice were exposed to aerosolized 2.5% ovalbumin solution in sterile saline for 30 minutes 3 days a week for 8 weeks, starting 7 days after the last IP administration (21st day). After exposure to OVA, mice were observed for typical signs of AR including sneezing, runny nose, and nasal itching. The final diagnosis of AR was made by histopathological examination of the rhinotracheal tissues of mice. Results: In our study, all mice exposed to ovalbumin received histopathologic diagnosis of AR. Increased number of capillaries lymphocytes, polymorphonuclear leukocytes and eosinophilsper square millimetre of rhinotracheal tissues were calculated in the murine model of AR compared to the the control group. Conclusion: This study introduced a new AR model, not cited in the literature, and induced with the longest-term ovalbumin exposure in the literature. It was concluded that this model, known as the asthma model, can also be used to induce an AR model and can be used in studies investigating coexistence of allergic rhinitis and asthma.

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“…This mechanism has been investigated. For example, Meiling Chen 60 et al used histamine H1 receptor antagonists to inhibit the production of chemokines in the guinea pig model of ovalbumin-induced allergic rhinitis and histamine-induced human nasal epithelial cells by inhibiting ERK1/2 and NF-kappaB signaling cascades, and found that MCP levels could be suppressed, thereby reducing histamine levels.…”

Section: The Specific Effects Of the Main Chemokines In The Process O...mentioning

confidence: 99%

Role of Chemokines and Inflammatory Cells in Respiratory Allergy

Bao¹,

Zhu²

2022

JAA

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The idea of "one airway, one disease" has been gaining importance in the last decade. In the upper and lower airways, allergic mechanisms interact with each other. In the initial stage of respiratory allergic inflammation, allergens contact the respiratory epithelium, which produces chemokines and inflammatory factors, which cause allergic reactions by binding to the corresponding receptors and chemotactic various inflammatory cells to reach the epithelium and tissues. It also drives inflammatory cells to activate and produce more inflammatory factors, thus producing a cascade amplification effect. Inflammatory cell aggregation and activation are very complex and interact with each other in a lattice structure. By blocking the action of various chemokines, inflammatory cell aggregation is reduced, and ultimately the symptoms of respiratory allergy are alleviated. Chemokines can serve as cues for coordinated recruitment of immune cells into and out of tissues, as well as directing the spatial organization of immune cells within tissues and cellular interactions. Chemokines are critical in directing immune cell migration and thus have an important role in the direction of respiratory allergy: however, chemokines are also involved in the production and recruitment of immune cells that contribute to respiratory allergy. In this article, linking the upper and lower respiratory tracts. We review the role of the chemokine system in the respiratory immune response and discuss how respiratory disease modulates overall chemokines to shape the type and outcome of the immune response to the treatment of respiratory allergic disease so that we can further deepen our knowledge of chemokines in the direction of respiratory allergy. In the future, we can do drug research and development based on this network structure and explore new research directions.

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Desloratadine citrate disodium injection, a potent histamine H1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades

Cited by 15 publications

References 25 publications

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

A New Experimental Allergic Rhinitis Model in Mice

Role of Chemokines and Inflammatory Cells in Respiratory Allergy

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