Designment of polydopamine/bacterial cellulose incorporating copper (II) sulfate as an antibacterial wound dressing

Yang, Zhi-Fei; Feng, Feng; Jiang, Wenwen; Ma, Le; Liu, Mingzhuo; Li, Kai; Wan, Yizao; Ao, Haiyong

doi:10.1016/j.msec.2021.112591

Cited by 27 publications

(10 citation statements)

References 36 publications

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“…groups, [28] affirming successful MnO 2 /PDA@Cu preparation. Zeta potential measurements indicated that PDA increased MnO 2 nanosheet negativity from −16.5 to −30.1 mV, while additional Cu adsorption decreased MnO 2 /PDA to −5.1 mV (Figure 1d).…”

Section: Development Of Mno 2 /Pda@cu Nanosheetsmentioning

confidence: 84%

Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

Wang,

Fei,

Yin

et al. 2023

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The optimal treatment for tracheal tumors necessitates sequential tumor elimination and tracheal cartilage reconstruction. This study introduces an innovative inorganic nanosheet, MnO2/PDA@Cu, comprising manganese dioxide (MnO2) loaded with copper ions (Cu) through in situ polymerization using polydopamine (PDA) as an intermediary. Additionally, a specialized methacrylic anhydride modified decellularized cartilage matrix (MDC) hydrogel with chondrogenic effects is developed by modifying a decellularized cartilage matrix with methacrylic anhydride. The MnO2/PDA@Cu nanosheet is encapsulated within MDC‐derived microneedles, creating a photothermal‐controllable MnO2/PDA@Cu‐MDC microneedle. Effectiveness evaluation involved deep insertion of the MnO2/PDA@Cu‐MDC microneedle into tracheal orthotopic tumor in a murine model. Under 808 nm near‐infrared irradiation, facilitated by PDA, the microneedle exhibited rapid overheating, efficiently eliminating tumors. PDA's photothermal effects triggered controlled MnO2 and Cu release. The MnO2 nanosheet acted as a potent inorganic nanoenzyme, scavenging reactive oxygen species for an antioxidant effect, while Cu facilitated angiogenesis. This intervention enhanced blood supply at the tumor excision site, promoting stem cell enrichment and nutrient provision. The MDC hydrogel played a pivotal role in creating a chondrogenic niche, fostering stem cells to secrete cartilaginous matrix. In conclusion, the MnO2/PDA@Cu‐MDC microneedle is a versatile platform with photothermal control, sequentially combining antitumor, antioxidant, pro‐angiogenic, and chondrogenic activities to orchestrate precise tracheal tumor eradication and cartilage regeneration.

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Section: Development Of Mno 2 /Pda@cu Nanosheetsmentioning

confidence: 84%

Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

Wang,

Fei,

Yin

et al. 2023

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“…The researchers found that the release of Cu 2+ can be controlled by combining with PDA to achieve mild and longlasting antibacterial ability. Based on this, Ao and coworkers [77] designed an antibacterial material based on PDA-and Cu 2+ -loaded bacterial cellulose, and the antibacterial rate of the composite material against S. aureus and E. coli was as high as 99.9% (Figure 4b). In addition, PDA-assisted Cu 2+ antibacterial materials can also be an option for wound healing.…”

Section: Pda/metal Composite Synergistic Antibacterial Therapymentioning

confidence: 99%

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

Wang

Liu

2022

IJMS

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Polydopamine (PDA), as a mussel-inspired material, exhibits numerous favorable performance characteristics, such as a simple preparation process, prominent photothermal transfer efficiency, excellent biocompatibility, outstanding drug binding ability, and strong adhesive properties, showing great potential in the biomedical field. The rapid development of this field in the past few years has engendered substantial progress in PDA antibacterial materials. This review presents recent advances in PDA-based antimicrobial materials, including the preparation methods and antibacterial mechanisms of free-standing PDA materials and PDA-based composite materials. Furthermore, the urgent challenges and future research opportunities for PDA antibacterial materials are discussed.

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“…Current BC wound dressing lacks the capacity to facilitate the release of active constituents. [15][16][17] In a previous study, we reported that potato starch effectively controls the network structure of BC. [18] Therefore, asymmetric membranes can be prepared based on BC membranes by altering the fermentation conditions and starch gelatinization degree.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Asymmetric Bacterial Cellulose Membrane with Enhanced Anti‐Bacterial and Anti‐Inflammatory Activities for Promoting Infected Wound Healing

Wang

Sun

et al. 2023

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An asymmetric wound dressing acts as a skin‐like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver‐metal organic frameworks (Ag‐MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti‐bacterial activities. Compared to BC‐based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full‐thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC‐based dressing.

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Designment of polydopamine/bacterial cellulose incorporating copper (II) sulfate as an antibacterial wound dressing

Cited by 27 publications

References 36 publications

Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

Multifunctional Asymmetric Bacterial Cellulose Membrane with Enhanced Anti‐Bacterial and Anti‐Inflammatory Activities for Promoting Infected Wound Healing

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