Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

Abstract

The optimal treatment for tracheal tumors necessitates sequential tumor elimination and tracheal cartilage reconstruction. This study introduces an innovative inorganic nanosheet, MnO2/PDA@Cu, comprising manganese dioxide (MnO2) loaded with copper ions (Cu) through in situ polymerization using polydopamine (PDA) as an intermediary. Additionally, a specialized methacrylic anhydride modified decellularized cartilage matrix (MDC) hydrogel with chondrogenic effects is developed by modifying a decellularized cartilage matrix with methacrylic anhydride. The MnO2/PDA@Cu nanosheet is encapsulated within MDC‐derived microneedles, creating a photothermal‐controllable MnO2/PDA@Cu‐MDC microneedle. Effectiveness evaluation involved deep insertion of the MnO2/PDA@Cu‐MDC microneedle into tracheal orthotopic tumor in a murine model. Under 808 nm near‐infrared irradiation, facilitated by PDA, the microneedle exhibited rapid overheating, efficiently eliminating tumors. PDA's photothermal effects triggered controlled MnO2 and Cu release. The MnO2 nanosheet acted as a potent inorganic nanoenzyme, scavenging reactive oxygen species for an antioxidant effect, while Cu facilitated angiogenesis. This intervention enhanced blood supply at the tumor excision site, promoting stem cell enrichment and nutrient provision. The MDC hydrogel played a pivotal role in creating a chondrogenic niche, fostering stem cells to secrete cartilaginous matrix. In conclusion, the MnO2/PDA@Cu‐MDC microneedle is a versatile platform with photothermal control, sequentially combining antitumor, antioxidant, pro‐angiogenic, and chondrogenic activities to orchestrate precise tracheal tumor eradication and cartilage regeneration.

Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

“…The fabrication of MN@Ag@MSN@CeO 2 patch was achieved using a microforming method, [12,24] which was illustrated as Supplemental Figure S4. Initially, a predetermined quantity of 𝛾-PGA pregel solution containing Ag@MSN@CeO 2 was filled into the microcavities of the mold (Figure 2a1) and subjected to vacuum conditions for 30 min.…”

“…[11] Notably, these MN patches possess multiple micron/nano-scale tips with needle structures. [12] MN patches have been employed for the transdermal delivery of various substances, with the therapeutic agents encapsulated in the MN tips. [13] They can release drugs encapsulated in the tip of the MN through the biofilm into the deep dermis.…”