Designing responsive dressings for inflammatory skin disorders; encapsulating antioxidant nanoparticles into biocompatible electrospun fibres

Brooker, Charles; d’Arcy, Richard; Mele, Elisa; Willcock, Helen

doi:10.1039/d0sm01987a

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…These data corroborate previous works that have demonstrated PPS-NPs reduce TNF-α levels in various inflammatory disease models. 26,34,45 Although not completely understood, aberrant complement activation also ensues after transplantation, with the formation of the terminal cytolytic membrane attack complex (C5-9b, also referred to as the membrane attack complex, MAC), inducing direct renal injury via apoptosis of epithelial tubular cells 46 . During NMP, there was a significant reduction in soluble MAC (sC5-9b) in the perfusate of PPS-NP treated kidneys (p≤0.01), with a 1.72x lower concentration of sC5-9b in the PPS-NP treated kidneys at 3 hrs (p≤0.0001) (Figure 6C).…”

Section: Mechanistic Insights: Pps-nps Are Anti-inflammatory and Bloc...mentioning

confidence: 99%

Antioxidant Polysulfide Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation

Stone

d’Arcy

Geraghty³

et al. 2023

Preprint

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Introduction: Ischaemia-reperfusion injury (IRI) results in the pathophysiological generation of reactive oxygen species (ROS) with concurrent activation of the complement cascade. This manifests as delayed graft function, which has a significant impact on the longevity of the graft. We aimed to evaluate if ROS scavenging nanoparticles can be used to mitigate IRI related injury during normothermic machine perfusion (NMP). Methods: A randomised, two-stage, preclinical trial was used to assess the impact of poly(propylene sulfide) (polysulfide) nanoparticles (PPS-NPs) on parameters associated with IRI in a renal NMP system (experiment 1, n=6 vs 6). Paired porcine kidneys were randomised to receive either an NP-preservation flush followed by 6 hours of NMP with NP-perfusate, or control preservation flush and standard NMP. Following this, an allogeneic transplant- reperfusion model was used to evaluate if treatment with PPS-NPs improved renal haemodynamics post-transplantation (experiment 2, n=6 vs 6). Kidneys were perfused for 3 hours with or without NP, before being reperfused on a circuit primed with matched blood from genetically different donor pigs for 6 hours, without immunosuppression. Results: In experiment 1, all kidneys perfused well for 6 hours with physiological renal haemodynamics and biochemistry. Kidneys perfused with PPS-NPs had improved regional tissue perfusion on infra-red imaging. In experiment 2, renal haemodynamics were significantly improved during allogeneic reperfusion (post-transplant) after treatment with NP. Complement activation remained significantly lower in treated kidneys with a diminished TNF-a response. This translated into an improvement in tissue integrity. Conclusion: IRI was ameliorated following treatment with NPs during preservation and NMP. This was evidenced by an improvement in renal haemodynamics and diminished inflammatory markers upon reperfusion with allogeneic blood.

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Section: Mechanistic Insights: Pps-nps Are Anti-inflammatory and Bloc...mentioning

confidence: 99%

Antioxidant Polysulfide Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation

Stone

d’Arcy

Geraghty³

et al. 2023

Preprint

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“…Brooker et al designed anti-inflammatory fibrous sheets that were synthesized from a propylene sulfide monomer via nanoemulsion polymerization before being electrospun into PEO fibers. This nanofiber exhibited high cytocompatibility when applied to human dermal fibroblasts ( Brooker et al, 2021 ). On the occasion of psoriasis, the commercially available poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three compounds, namely, salicylic acid, methyl salicylate, and capsaicin, which constitute the main agents to alleviate psoriatic symptoms.…”

Section: Nanoparticlesmentioning

confidence: 99%

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Qin

Dai

et al. 2022

Front. Bioeng. Biotechnol.

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Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

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“…20,40 The oxidation of aliphatic thioethers to sulfoxides or sulfones has been extensively applied in polymeric materials to increase the hydrophilicity of the chain. 23,[41][42][43][44] An aromatic ring adjacent to the thioether group could enhance the nucleophilicity of the sulfur atom towards H 2 O 2 . 45 However, it is known that the oxidation of aromatic thioethers to the corresponding sulfoxide and sulfone is insufficient to achieve a desired solubility switch.…”

Section: Introductionmentioning

confidence: 99%

Thioanisole ester based logic gate cascade to control ROS-triggered micellar degradation

et al. 2022

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Designing responsive dressings for inflammatory skin disorders; encapsulating antioxidant nanoparticles into biocompatible electrospun fibres

Abstract: Antioxidant polysulfide nanoparticles can be electrospun within nanofibre scaffold patches to provide anti-inflammatory action.

Cited by 13 publications

References 38 publications

Antioxidant Polysulfide Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation

Antioxidant Polysulfide Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Thioanisole ester based logic gate cascade to control ROS-triggered micellar degradation

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