Designing Potent Derivatives of Ovokinin(2-7), an Anti-hypertensive Peptide Derived from Ovalbumin

Matoba, Nobuyuki; Yamada, Yuko; Usui, Hachiro; Nakagiri, Ryusuke; Yoshikawa, Masaaki

doi:10.1271/bbb.65.736

Cited by 50 publications

(29 citation statements)

References 10 publications

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“…Anyhow, it seems that no general strategy for improving bioavailability of antihypertensive peptides exists and due to the number of processes involved and different characteristics of peptides depending on the sequence each case must be studied. Many strategies are currently demonstrated for enhancing bioavailability [171], among them microencapsulation for controlled release of the active compounds, stabilization of the active molecules to improve transportation through the intestinal barrier and provide resistance against degradation, and development of highly stabile peptide analogues [172][173][174].…”

Section: Bioavailabilitymentioning

confidence: 99%

“…in the regulation of blood pressure and circulation, and these receptors are related to the antihypertensive properties of some food derived peptides. Other vasodilatory substances, such as ET-1, have also been suggested to be involved in the antihypertensive effects of food-derived peptides [173,178,179]. However, peptide sequences derived specifically from plant proteins inducing endothelial NO liberation have not been reported this far.…”

Section: Health Benefitsmentioning

confidence: 99%

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Antihypertensive Properties of Plant Protein Derived Peptides

Pihlanto¹,

Mäkinen²

2013

Bioactive Food Peptides in Health and Disease

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Section: Bioavailabilitymentioning

confidence: 99%

Section: Health Benefitsmentioning

confidence: 99%

Antihypertensive Properties of Plant Protein Derived Peptides

Pihlanto¹,

Mäkinen²

2013

Bioactive Food Peptides in Health and Disease

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“…This subunit was expressed in E. coli, recovered from the soluble fraction and purified by chromatography. The Arg-Pro-Leu-Lys-Pro-Trp peptide was released from recombinant containing subunit after digestion by trypsin and chymotrypsin [52]. Feeney et al [53] reported that the construction of glutenin genes and their expression in E.coli is a viable method for producing peptides.…”

Section: Pepsinmentioning

confidence: 99%

Food-derived Bioactive Peptides - Opportunities for Designing Future Foods

Korhonen

Pihlanto²

2003

CPD

691

430

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Dietary proteins are known to carry a wide range of nutritional, functional and biological properties. Nutritionally, the proteins are a source of energy and amino acids, which are essential for growth and maintenance. Functionally, the proteins contribute to the physicochemical and sensory properties of various protein-rich foods. Furthermore, many dietary proteins possess specific biological properties which make these components potential ingredients of functional or health-promoting foods. Many of these properties are attributed to physiologically active peptides encrypted in protein molecules. Particularly rich sources of such peptides are milk and egg, but they are also found in meat of various kinds as well as many plants. These peptides are inactive within the sequence of parent protein and can be released during gastrointestinal digestion or food processing. Depending on the amino acid sequence, these peptides may exert a number of different activities in vivo, affecting, e.g., the cardiovascular, endocrine, immune and nervous systems in addition to nutrient utilization. There is increasing commercial interest in the production of bioactive peptides from various sources. Industrial-scale production of such peptides is, however, hampered by the lack of suitable technologies. Bioactive peptides can also be produced from milk proteins through fermentation of milk, by starters employed in the manufacture of fermented milks or cheese. In particular, antihypertensive peptides have been identified in fermented milk, whey and ripened cheese. A few of these peptides have been commercialised in the form of fermented milks. There is a need to develop technologies which retain or even enhance the activity of bioactive peptides in food systems. Also, it is essential to study the optimum utilization of such peptides during passage through the gastrointestinal tract.

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“…Its vasorelaxing activity was mediated by the B1 receptor. On the other hand, Ovokinin(2-7) (RADHPF) was isolated from a trypsin digest of ovalbumin based on vasorelaxing activity in mesenteric artery isolated from SHR [52]. It showed a weak affinity for the AT2 receptor.…”

Section: C) Egg Proteinsmentioning

confidence: 99%

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

Yoshikawa

2015

Peptides

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We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects. β-Lactotensin derived from β-lactoglobulin, the first natural ligand for the NTS2 receptor, showed memory-consolidating, anxiolytic-like, and hypocholesterolemic effects. Weak agonist peptides for the complements C3a and C5a receptors were released from many proteins and exerted various central effects. Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained. Based on these study, new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.

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Designing Potent Derivatives of Ovokinin(2-7), an Anti-hypertensive Peptide Derived from Ovalbumin

Cited by 50 publications

References 10 publications

Antihypertensive Properties of Plant Protein Derived Peptides

Antihypertensive Properties of Plant Protein Derived Peptides

Food-derived Bioactive Peptides - Opportunities for Designing Future Foods

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

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