Designing membrane electrochemical reactors for oxidoreductase-catalysed synthesis

Délécouls-Servat, K; Basseguy, Régine; Bergel, Alain

doi:10.1016/s1567-5394(01)00132-3

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…[16][17][18] Although the electron pair is preferably transferred to the oxidised cofactor, the direct reduction of the substrate also takes place to a minor extent. Since the direct reduction is unselective, both enantiomers are formed.…”

Section: Batch Reactionsmentioning

confidence: 99%

Electroenzymatic synthesis of chiral alcohols in an aqueous–organic two-phase system

Hildebrand

Lütz

2007

Tetrahedron: Asymmetry

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Section: Batch Reactionsmentioning

confidence: 99%

Electroenzymatic synthesis of chiral alcohols in an aqueous–organic two-phase system

Hildebrand

Lütz

2007

Tetrahedron: Asymmetry

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“…In previous studies, mediated electron transfer (MET) based on the utilization of a free electron mediator is the dominant method to perform the regeneration of NAD(P)H. Cp*Rh(bpy)L has been used as an electron mediator to facilitate the reduction of acetophenone, cyclohexanone, and 4-phenyl-2-butanone to produce ( R )-phenylethanol, cyclohexanol, and ( S )-4-phenyl-2-butanol. ,− The methyl viologen (MV) coupling with diaphorase can be used to regenerate NADH, which has been applied in the reduction of cyclohexanone, 2-methyl-cyclohexanone, pyruvate, and benzoylformate to produce cyclohexanol, (1 S ,2 S )-(+)-2-methylcyclohexanol, d -lactate, and ( R )-mandelate. − Recently, the Minteer research group developed a biphasic bioelectrocatalytic synthesis method to prepare chiral β-hydroxy nitriles . In their research, diaphorase was immobilized by a cobaltocene-modified poly(allylamine) ( Cc -PAA) redox polymer on the surface of the cathode (DH/ Cc -PAA biocathode) to achieve an effective bioelectrocatalytic NADH regeneration.…”

Section: The Applications Of Bioelectrocatalysismentioning

confidence: 99%

Fundamentals, Applications, and Future Directions of Bioelectrocatalysis

et al. 2020

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Bioelectrocatalysis is an interdisciplinary research field combining biocatalysis and electrocatalysis via the utilization of materials derived from biological systems as catalysts to catalyze the redox reactions occurring at an electrode. Bioelectrocatalysis synergistically couples the merits of both biocatalysis and electrocatalysis. The advantages of biocatalysis include high activity, high selectivity, wide substrate scope, and mild reaction conditions. The advantages of electrocatalysis include the possible utilization of renewable electricity as an electron source and high energy conversion efficiency. These properties are integrated to achieve selective biosensing, efficient energy conversion, and the production of diverse products. This review seeks to systematically and comprehensively detail the fundamentals, analyze the existing problems, summarize the development status and applications, and look toward the future development directions of bioelectrocatalysis. First, the structure, function, and modification of bioelectrocatalysts are discussed. Second, the essentials of bioelectrocatalytic systems, including electron transfer mechanisms, electrode materials, and reaction medium, are described. Third, the application of bioelectrocatalysis in the fields of biosensors, fuel cells, solar cells, catalytic mechanism studies, and bioelectrosyntheses of high-value chemicals are systematically summarized. Finally, future developments and a perspective on bioelectrocatalysis are suggested.

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“…Further developments in membrane electrochemical reactors occurred with the introduction of flat dialysis membrane and flat ultra-filtration membrane within the reactor. [122,123] Basséguy et al developed two membrane reactors based on dialysis membrane (D-MER) and ultrafiltration membrane (UF-MER) where the catalyst was confined to a membrane which separates the electrochemical regeneration and cyclohexanol production processes. [111] [Cp*Rh (bpy)(H 2 O)] 2 + was used as the mediator for NADH regeneration.…”

Section: Mediatedmentioning

confidence: 99%

Recent Progress and Perspectives on Electrochemical Regeneration of Reduced Nicotinamide Adenine Dinucleotide (NADH)

Immanuel

Sivasubramanian

Gul

et al. 2020

Chemistry An Asian Journal

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NAD is a cofactor that maintains cellular redox homeostasis and has immense industrial and biological significance. It acts as an enzymatic mediator in several biocatalytic electrochemical reactions and undergoes oxidation/reduction to form NAD + or NADH, respectively. The NAD redox couple (NAD + /NADH) mostly exists in enzyme-assisted metabolic reactions as a coenzyme during which electrons and protons are transferred. NADH shuttles these charges between the enzyme and the substrate. In order to understand such complex metabolic reactions, it is vital to study the bio-electrochemistry of NADH. In addition, the regeneration of NADH in industries has attracted significant attention due to its vast usage and high cost. To make biocatalysis economically viable, primary methods of NADH regeneration including enzymatic, chemical, photochemical and electrochemical methods are widely used. This review is mainly focused on the electrochemical reduction of NAD + to NADH with specific details on the mechanism and kinetics of the reaction. It provides emphasis on the different routes (direct and mediated) to electrochemically regenerate NADH from NAD + highlighting the NAD dimer formation. Also, it describes the electrocatalysts developed until now and the scope for development in this area of research.

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Designing membrane electrochemical reactors for oxidoreductase-catalysed synthesis

Cited by 12 publications

References 7 publications

Electroenzymatic synthesis of chiral alcohols in an aqueous–organic two-phase system

Electroenzymatic synthesis of chiral alcohols in an aqueous–organic two-phase system

Fundamentals, Applications, and Future Directions of Bioelectrocatalysis

Recent Progress and Perspectives on Electrochemical Regeneration of Reduced Nicotinamide Adenine Dinucleotide (NADH)

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