Designing Fractal Nanostructured Biointerfaces for Biomedical Applications

Zhang, Pengchao; Wang, Shutao

doi:10.1002/cphc.201301230

Cited by 39 publications

(21 citation statements)

References 120 publications

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“…Increasing the electric potential accelerates the kinetics of electrodeposition, which promotes irregular growth of nanostructures. While relatively smooth structures are generated at low deposition potentials, fractal Au nanostructures can be obtained at higher deposition potentials [41]. In this study, varying deposition time (600 s, 900 s, 1200 s, 1800 s, 2100 s, 2700 s and 3600 s) and voltages (−0.3 V,−0.5 V and −0.7 V) were tested for generating gold nanostructured electrodes.…”

Section: Resultsmentioning

confidence: 99%

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Rough Gold Electrodes for Decreasing Impedance at the Electrolyte/Electrode Interface

Koklu

Sabuncu

Beşkök

2016

Electrochimica Acta

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Electrode polarization at the electrolyte/electrode interface is often undesirable for bio-sensing applications, where charge accumulated over an electrode at constant potential causes large potential drop at the interface and low measurement sensitivity. In this study, novel rough electrodes were developed for decreasing electrical impedance at the interface. The electrodes were fabricated using electrochemical deposition of gold and sintering of gold nanoparticles. The performances of the gold electrodes were compared with platinum black electrodes. A constant phase element model was used to describe the interfacial impedance. Hundred folds of decrease in interfacial impedance were observed for fractal gold electrodes and platinum black. Biotoxicity, contact angle, and surface morphology of the electrodes were investigated. Relatively low toxicity and hydrophilic nature of the fractal and granulated gold electrodes make them suitable for bioimpedance and cell electromanipulation studies compared to platinum black electrodes which are both hydrophobic and toxic.

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Section: Resultsmentioning

confidence: 99%

“…Also the hydrophilic nature of the rough gold surface compared to PB surface offers a major advantage for microfluidic systems. Therefore, rough gold electrodes can be a favorable alternative to PB and other materials to reduce EP owing to its dendritic and recursively constructed shape to maximize effective surface area [41]. …”

Section: Introductionmentioning

confidence: 99%

Rough Gold Electrodes for Decreasing Impedance at the Electrolyte/Electrode Interface

Koklu

Sabuncu

Beşkök

2016

Electrochimica Acta

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“…Recent advances in the field of nanotechnology offer powerful solutions 65 - 67 resulting in a wide range of in-depth characterizations of CTCs while drastically reducing costs. Ultimately, deployment of these emerging advances will bring oncology closer to the goal of personalized care.…”

Section: Nanovelcro Ctc Assays: Three Generations Of Developmentmentioning

confidence: 99%

Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells

Chen¹,

Zhu²,

Lu³

et al. 2016

Theranostics

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Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs will reveal unprecedented insight into the pathogenic mechanisms driving lethal disease. Nanomaterial-embedded cancer diagnostic platforms, i.e., NanoVelcro CTC Assays represent a unique rare-cell sorting method that enables detection isolation, and characterization of CTCs in peripheral blood, providing an opportunity to noninvasively monitor disease progression in individual cancer patients. Over the past decade, a series of NanoVelcro CTC Assays has been demonstrated for exploring the full potential of CTCs as a clinical biomarker, including CTC enumeration, phenotyping, genotyping and expression profiling. In this review article, the authors will briefly introduce the development of three generations of NanoVelcro CTC Assays, and highlight the clinical applications of each generation for various types of solid cancers, including prostate cancer, pancreatic cancer, lung cancer, and melanoma.

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“…With miRNA roles having been identified during cell proliferation or apoptosis, evidence is mounting that various diseases, including cancers, are impacted by a higher or lower expression of multiple miRNAs . In aiming to realize high‐sensitivity detection of miRNAs, several signal‐amplification strategies have been developed based mainly on the integration of various nanomaterials and molecular biology pathways, such as polymerase chain reaction (PCR), hybridization chain reaction (HCR), and so on . Among these strategies, graphene oxide (GO), a 2D carbon nanomaterial with extraordinary physical and chemical properties, is attracting widespread interest for nucleic acid quantification .…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Photonic Barcodes with Graphene Oxide Encapsulation for Multiplexed MicroRNA Quantification

Bian

Wang

et al. 2018

Small

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Multiplexed microRNA (miRNA) quantification has a demonstrated value in clinical diagnosis. In this paper, novel mussel-inspired photonic crystal (PhC) barcodes with graphene oxide (GO) encapsulation for multiplexed miRNA detection are presented. Using the excellent adhesion capability of polydopamine, the dispersed GO particles can be immobilized on the surfaces of the PhC barcodes to form an additional functional layer. The GO-decorated PhC barcodes have constant characteristic reflection peaks because the GO immobilization process not only maintains their periodic microstructure but also enhances their stability and anti-incoherent lightscattering capability. The immobilized GO particles are shown to enable high-sensitivity miRNA screening on the surface of the PhC barcodes by integration with a hybridization chain reaction amplification strategy. Because the PhC barcodes have stable encoding reflection peaks, multiplexed low-abundance miRNA quantification can also be achieved rapidly, accurately, and reproducibly by employing different GO-decorated PhC barcodes. These features should make GO-encapsulated PhC barcodes ideal for many practical applications.

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Designing Fractal Nanostructured Biointerfaces for Biomedical Applications

Cited by 39 publications

References 120 publications

Rough Gold Electrodes for Decreasing Impedance at the Electrolyte/Electrode Interface

Rough Gold Electrodes for Decreasing Impedance at the Electrolyte/Electrode Interface

Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells

Bioinspired Photonic Barcodes with Graphene Oxide Encapsulation for Multiplexed MicroRNA Quantification

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