Designing electrospun nanofiber mats to promote wound healing – a review

Abstract

Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials-biology interface. In this review, first we briefly discuss the wound healing process and then highlight recent advances in drug release, biologics encapsulation, and antibacterial activity that have been demonstrated via electrospinning. While this versatile biomaterial has shown much progress, commercializing nanofiber mats that fully address the needs of an individual patient remains an ambitious challenge.

Wound Healing and Electrospun Wound Dressings: Review

“…Bu yöntemle nanoliflere antibiyotik, antiseptik, antibakteriyel, anestezik, vitamin ve çeşitli büyüme faktörleri yüklene-bilir. 55 Koaksiyel nanolif elde edilmesi yönteminde iki ya da daha fazla polimer çözeltisi elektro-çekim cihazının koaksiyel kapiler besleme ünitesinden geçerek toplama levhasına çekirdek-kabuk (coreshell) yapısında nanolif şeklinde toplanmaktadır (Şekil 3). 56 Koaksiyel elektro-çekim 2003 yılında bulunmuş ve hızla popüler hâle gelmiştir.…”

Electrospun nanofibrous materials for wound healing applications

“…Incorporation of active agents into polymeric nanofibers is always of great interest in improved biomedical applications. To date, a variety of bioactive agents including antimicrobial agents, growth factors, genes, vitamins, metal, and metal oxide nanoparticles have been introduced into polymeric nanofibers for enhanced wound healing [12,21,22,26]. A recent study by Li et al [37] demonstrated the incorporation of vitamin A palmitate (VA) and vitamin E TPGS (VE), common derivatives of the unstable vitamins A and E into biodegradable GE nanofibers using electrospinning.…”

“…Electrospun nanofibers have received tremendous attention toward energy, environmental, and biomedical applications due to their exceptional characteristic features [12][13][14][15][16]. Electrospun nanofiber scaffolds offer ideal characteristics of wound dressings, that is, high surface area to volume ratio, adsorption of exudates, interconnected nanoporosity, controlled drug or biomolecules release, cell respiration, flexibility, and better sorption of proteins; thus, the electrospun nanofibers produced from different electrospinning approaches including blend, coaxial, emulsion electrospinning, and also postspinning modifications have been extensively used in wound healing applications [17][18][19][20][21][22]. Different biomolecules involved wound healing, fabrication of nanofibers, and current strategies used in electrospinning to produce wound dressing material were reviewed by Abrigo et al [17].…”

Tolnaftate-Loaded PolyacrylateElectrospun Nanofibers for an Impressive Regimen on Dermatophytosis

“…Inherent nano scaled interconnected voids/pores within these nano fibers also restrict further penetration of pathogen at the application site, and provide desirable cell interactions to make them competent for designing regenerative medicine [11,12]. Additionally, the incorporation of bioactive agents during the fabrication of nano fibers cater specific and efficient exercising for healing wounds, skin regeneration, gene/DNA delivery, and tissue repairing [13].…”