Designing Biomaterials for 3D Printing

Guvendiren, Murat; Molde, Joseph; Soares, Rosane Michele Duarte; Kohn, Joachim

doi:10.1021/acsbiomaterials.6b00121

Cited by 628 publications

(519 citation statements)

References 184 publications

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“…4 The most commonly used bioprinting techniques are extrusion-based, particle fusion-based, light-induced, and inkjet-based bioprinting. [1][2][3][5][6][7][8][9] Extrusion-based bioprinting is one of the most popular techniques due to compatibility with a variety of bioink, ease of operation and relatively low cost. 3,10 Among various bioinks, hydrogels represent a class of promising materials because they provide a highly hydrated, biocompatible, 3D environment.…”

Section: Introductionmentioning

confidence: 99%

3D bioprinting of liver-mimetic construct with alginate/cellulose nanocrystal hybrid bioink

Lin²,

et al. 2018

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Abstract3D bioprinting is a novel platform for engineering complex, three-dimensional (3D) tissues that mimic real ones. The development of hybrid bioinks is a viable strategy that integrates the desirable properties of the constituents. In this work, we present a hybrid bioink composed of alginate and cellulose 2 nanocrystals (CNCs) and explore its suitability for extrusion-based bioprinting. This bioink possesses excellent shear-thinning property, can be easily extruded through the nozzle, and provides good initial shape fidelity. It has been demonstrated that the viscosities during extrusion were at least two orders of magnitude lower than those at small shear rates, enabling the bioinks to be extruded through the nozzle (100 μm inner diameter) readily without clogging. This bioink was then used to print a liver-mimetic honeycomb 3D structure containing fibroblast and hepatoma cells. The structures were crosslinked with CaCl 2 and incubated and cultured for 3 days. It was found that the bioprinting process resulted in minimal cell damage making the alginate/CNC hybrid bioink an attractive bioprinting material.Graphical abstract

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Section: Introductionmentioning

confidence: 99%

3D bioprinting of liver-mimetic construct with alginate/cellulose nanocrystal hybrid bioink

Lin²,

et al. 2018

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“…When cells or biochemical molecules are incorporated in these materials, it is considered a bioink. This form of bioprinting is increasing in popularity, as it allows you to not only provide a 3D environment that mimics native extracellular matrix [17], it also allows for patterning of the cells [18,19].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Current developments in 3D bioprinting for tissue engineering

Cornelissen

Faulkner-Jones

Shu

2017

Current Opinion in Biomedical Engineering

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This version is available at https://strathprints.strath.ac.uk/61660/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTCurrent developments in 3D bioprinting for tissue engineering AbstractThe field of 3-dimensional (3D) bioprinting have enjoyed rapid development in the past few years for the applications in tissue engineering and regenerative medicine. In this review, we summarize the most updated developments in 3D bioprinting for the applications in the tissue engineering with a focus on the printable biomaterials used as bioinks. These developments include 1) novel printing regimes have been enabled by the use of fugitive inks for the creation of intricate structures e.g. vascularized tissue constructs; 2) mechanical strength of printed constructs can be enhanced by co-printing soft and hard biomaterials; 3) bioprinted in-vitro models for drug testing applications are closer to reality. We conclude that the research and application of new bioinks will remain the key highlights of the future developments in 3D bioprinting for tissue engineering.

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“…Another method for tissue scaffold fabrication is 3D printing, an additive manufacturing technique that allows fabrication of modular and patientspecific scaffolds with high structural complexity and design flexibility. This technology enables the design and fabrication of constructs based on tissue images captured with commonly used medical imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) [166]. Common 3D printing methods involve the use of heat, toxic organic solvents or toxic photoinitiators for fabrication of synthetic scaffolds.…”

Section: Fabrication Of Porous Biopusmentioning

confidence: 99%