Designer Self‐Assembling Peptide Materials for Diverse Applications

Hauser, Charlotte; Zhang, Shuguang

doi:10.1002/masy.200900171

Cited by 12 publications

(9 citation statements)

References 50 publications

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“…Then hydrophobic interactions play an important role by excluding surrounding aqueous media between hydrophobic faces of neighboring peptides. β-sheet bilayers that results from parallel or anti-parallel alignment of peptides form fibrils via intra and intermolecular hydrogen bonds and electrostatic interactions [[10], [11], [12], [13]]. Despite the first generation of self-assembling peptides which associate into nanofibers, other hierarchical structural arrays including ribbons, tapes, fibrils can also be designed [3,[14], [15], [16]].…”

Section: Design Principles Of Self-assembling Peptides and Mechanism mentioning

confidence: 99%

Self-assemble peptide biomaterials and their biomedical applications

Chen

Zou

2019

Bioactive Materials

186

148

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Inspired by self-assembling peptides found in native proteins, deliberately designed engineered peptides have shown outstanding biocompatibility, biodegradability, and extracellular matrix-mimicking microenvironments. Assembly of the peptides can be triggered by external stimuli, such as electrolytes, temperature, and pH. The formation of nanostructures and subsequent nanocomposite materials often occur under physiological conditions. The respective properties of side chains in each amino acids provide numerous sites for chemical modification and conjugation choices of the peptides, enabling various resulting supramolecular nanostructures and hydrogels with adjustable mechanical and physicochemical properties. Moreover, additional functionalities can be easily induced into the hydrogels, including shear-thinning, bioactivity, self-healing, and shape memory. It further broaden the scope of application of self-assemble peptide materials. This review outlines designs of self-assembly peptide (β-sheet, α-helix, collagen-like peptides, elastin-like polypeptides, and peptide amphiphiles) with potential additional functionalities and their biomedical applications in bioprinting, tissue engineering, and drug delivery.

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Section: Design Principles Of Self-assembling Peptides and Mechanism mentioning

confidence: 99%

Self-assemble peptide biomaterials and their biomedical applications

Chen

Zou

2019

Bioactive Materials

186

148

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“…As an attractive property, these systems provide hydrogels with a high water content and structural integrity near to fibrocartilage. Repeating positive and negative l-amino acids that self-assemble into nanofibres through β-sheet interactions, are the other design of nonafibre scaffolds [159]. This material has been used to stimulate the growth of chondrocytes, and the fabrication of main hyaline cartilage markers by Liu et al [160].…”

Section: The Next Generation Biomaterials For Cartilage Tissue Enginementioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

100

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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“…It was initially suggested that β-sheet bilayers stack together via H-bonding and electrostatic interactions. 23,56,57 Recently, Cormier and his colleagues have investigated the hierarchy of RADA16-I (RADARADARADARADA) peptide nanofibers using high resolution techniques, i.e. solid state nuclear magnetic resonance (NMR) spectroscopy and wide angle X-ray diffraction (Fig.…”

Section: Mechanism and Hierarchy Of Peptide Assemblymentioning

confidence: 99%

Engineering β-sheet peptide assemblies for biomedical applications

Cai

Chen

et al. 2016

Biomater. Sci.

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Hydrogels have been widely studied in various biomedical applications, such as tissue engineering, cell culture, immunotherapy and vaccines, and drug delivery. Peptide-based nanofibers represent a promising new strategy for current drug delivery approaches and cell carriers for tissue engineering. This review focuses on the recent advances in the use of self-assembling engineered β-sheet peptide assemblies for biomedical applications. The applications of peptide nanofibers in biomedical fields, such as drug delivery, tissue engineering, immunotherapy, and vaccines, are highlighted. The current challenges and future perspectives for self-assembling peptide nanofibers in biomedical applications are discussed.

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Designer Self‐Assembling Peptide Materials for Diverse Applications

Cited by 12 publications

References 50 publications

Self-assemble peptide biomaterials and their biomedical applications

Self-assemble peptide biomaterials and their biomedical applications

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Engineering β-sheet peptide assemblies for biomedical applications

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