Design, Synthesis of Some Novel Thiazolidin-4-one Derivatives Bearing Benzimidazole Nucleus and Biological Evaluation of their Possible in vitro Antiinflammatory as Cyclooxygenase Inhibitors and Antioxidant Activity

Sahoo, Ujjwal; Seth, Amit; Balaraman, R; Velmurugan, Rajendran

doi:10.14233/ajchem.2015.17788

Cited by 3 publications

(1 citation statement)

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“…The solid was purified by chromatography over silica gel using CH2Cl2/CH3OH (9:1) as the eluent to yield compounds. Yellow [36] and Sahoo et al [37] followed with minor modification. The reaction mixture was consisting of test compound at different concentrations and 1 mL of 1 mM albumin solution in 0.2 M phosphate buffer.…”

Section: Synthesis Of 1-(34-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxymentioning

confidence: 99%

Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory

Sohilait¹,

Pranowo²,

Haryadi³

2018

Asian J. Chem.

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Synthesis of new asymmetrical curcumin analogue of 1-(3,4-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one via condensation reaction between vanillinacetone and veratraldehyde in ethanol has been performed. The in vitro anti-inflammatory activities of the synthesized compounds showed excellent anti-inflammatory activity. In vitro anti-inammatory activity by using inhibition of albumin denaturation technique compared to standard dichlorofenac. Molecular docking studies were performed, where docking of the compound into 6COX active site suggested that it could exert its anti-inflammatory potential by cyclooxygenase inhibition.

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Section: Synthesis Of 1-(34-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxymentioning

confidence: 99%

Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory

Sohilait¹,

Pranowo²,

Haryadi³

2018

Asian J. Chem.

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Synthesis and in vitro α-chymotrypsin inhibitory activity of 6-chlorobenzimidazole derivatives

Siddiqui

Farooq

Marasini

et al. 2016

Bioorganic & Medicinal Chemistry

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Potent Biological Agent Benzimidazole–a Review

Prasad

Kanvinde

Raja

2016

Int J Pharm Pharm Sci

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<p>Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, and antiviral activity) of bezimidazole are collected and summarized here. Large numbers of drugs are available to treat various diseases, but they are associated with some drawbacks like resistance, toxicities and other adverse effects. To combat with these problems there is need to discover and synthesize newer chemical entities with better efficacy and novel mechanism of action. The benzimidazole ring is an important pharmacophore in modern drug discovery. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research. There is still scope for more research work to be done in this field to find a novel agent. The versatility of new generation benzimidazole would represent a fruitful pharmacophore for further development of better medicinal agents. Therefore this substrate has a tremendous scope for the discovery of new, better, safe and more potent biological agents.</p>

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Design, Synthesis of Some Novel Thiazolidin-4-one Derivatives Bearing Benzimidazole Nucleus and Biological Evaluation of their Possible in vitro Antiinflammatory as Cyclooxygenase Inhibitors and Antioxidant Activity

Cited by 3 publications

References 0 publications

Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory

Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory

Synthesis and in vitro α-chymotrypsin inhibitory activity of 6-chlorobenzimidazole derivatives

Potent Biological Agent Benzimidazole–a Review

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