Potent Biological Agent Benzimidazole–a Review

Abstract

<p>Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, and antiviral activity) of bezimidazole are collected and summarized here. Large numbers of drugs are available to treat various diseases, but they are associated with some drawbacks like resistance, toxicities and other adverse effects. To combat with these problems there is need to discover and synthesize newer chemical entities with better efficacy and novel mechanism of action. The benzimidazole ring is an important pharmacophore in modern drug discovery. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research. There is still scope for more research work to be done in this field to find a novel agent. The versatility of new generation benzimidazole would represent a fruitful pharmacophore for further development of better medicinal agents. Therefore this substrate has a tremendous scope for the discovery of new, better, safe and more potent biological agents.</p>

Silica core–shell particles for the dual delivery of gentamicin and rifamycin antibiotics

“…To clarify this point, mass spectrometry analysis of a particle suspension supernatant allowed us to identify the presence of gentamicin and rifamycin 40,41 (ESI-5 †) and further confirmed the release of both antibiotics from the core-shell particles. The kinetics profiles revealed that 43% of the rifamycin is released during the first 30 minutes while the release of 50% of the gentamicin requires a four time longer incubation time.…”

Structural and theoretical studies of 4-chloro-2-methyl-6-oxo-3,6-dideuteropyrimidin-1-ium chloride (d 6)

“…Pyrimidines represent one of the most active classes of compounds, possessing a wide spectrum of biological activities such as significant in vitro activity against unrelated DNA and RNA viruses including polio herpes viruses, and diuretic, antitumor, anti-HIV, and cardiovascular (Kappe, 1993) activity. In addition to this, various analogs of pyrimidines have been found to possess antibacterial (Sharma et al, 2004;Prakash et al, 2004;Botta et al, 1992;Cieplik et al, 2015), antifungal (Agarwal et al, 2000;Oliver et al, 2016), antileishmanial (Ram et al, 1992;Alptuzun et al, 2013), anti-inflammatory (Amir et al, 2007;Sondhi et al, 2008), analgesic (Vega et al, 1990; Gupta et al, 2011), anti- hypertensive (Hannah & Stevens, 2003;Rana et al, 2004;Alam et al, 2010), antipyretic (Smith & Kan, 1964;El-Sharkawy et al, 2018), antiviral (Balzarini & McGuigan, 2002;Nasr & Gineinah, 2002), antidiabetic (Lee et al, 2005;Reddy et al, 2019), antiallergic (Juby et al, 1979;Gupta et al, 1995), anticonvulsant (Gupta et al, 1994;Shaquiquzzaman et al, 2012), antioxidant (Krivonogov, et al, 2001;Abu-Hashem et al, 2010, antihistaminic (Prasad & Rahaman, 2008;Rahaman et al, 2009), herbicidal (Nezu et al, 1996;Li et al, 2018), and anticancer activities (Abu-Hashem et al, 2010Xie et al, 2009;Kaldrikyan et al, 2000;Mohamed et al, 2...…”

Synthesis, Characterization, and Evaluation of Antibacterial and Antidepressant Activities of Novel Tetrasubstituted Imidazole Derivatives

“…Changes in the imidazole structures have offered high biological activities that have proven useful for the development of new medicinal agents having improved potency and lesser toxicity. The present review highlights the various synthesized benzimidazoles and their derivatives possessing various activities such as analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, antiviral, antianxiety, acetylcholinesterase inhibitory, and diuretic activity [3].…”