Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

“…BTA dithiocarbamate and chalcone dithiocarbamate derivatives were synthesized by introducing various amines on dithiocarbamate side chain and evaluate for their antimitotic activity. Compound with 2-aminobenzothiazole as a side chain (239) displayed most promising antimitotic activity with IC 50 ¼ 1.52 mM [275]. Azam and coworkers synthesis of BTA-urea derivatives as a antiParkinsonian agents.…”

Synthesis of 5‐amino‐1,3,4‐thiadiazoles containing dithiocarbamate groups

“…It is a valuable pharmacophore that induces various biological activities when incorporated in a structure. Recently, various heterocyclic compounds containing dithiocarbamate groups including chromone‐dithiocarbamate, triazole‐dithiocarbamates, benzodioxole‐dithiocarbamates, benzimidazole‐dithiocarbamates, indole‐dithiocarbamates, and quinazolinone‐dithiocarbamate have been introduced as efficient building blocks with anticancer and antibacterial activities (Scheme B). For this purpose, attempts to incorporate dithiocarbamate functional group into heterocyclic skeletons have found especial interest for the designing of novel pharmaceuticals.…”

“…For this purpose, numerous methods are available in literature for the synthesis of heterocyclic compounds containing the dithiocarbamate moieties. Among them, direct C‐H functionalization of heterocyclic compounds with disulfiram, nucleophilic substitution of alkyl halides or tosylates with dithiocarbamic acid salts on the heterocyclic skeleton, and cyclization reaction of dithiocarbamate‐containing starting materials are noteworthy.…”

Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors

“…Dithiocarbamates are important pharmacophores owing to their lipophilicity, which is crucial for the delivery of central nervous system drugs to their site of action through the blood‐brain barrier. Medicinal chemists have studied dithiocarbamates extensively due to the fact that new effective compounds can be obtained by the bioisosteric replacement of a carbamate moiety with a dithiocarbamate moiety 13–20.…”