Design, synthesis, in vitro and in silico anti-cancer activity of 4H-chromenes with C4-active methine groups

Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds

“…Chromones constitute a vital group of heterocycles that serve as the framework for numerous commercial drugs and biological compounds. 59 Chromone derivatives exhibit various pharmacological activi-ties, such as anti-fungal, 60 anti-bacterial, 29a anti-inflammatory, 61 anti-oxidant, 62 anti-cancer, 63 anti-ulcer, 64 anti-HIV, 65 wound healing, 66 biocidal, 66 and immune-stimulatory properties (Fig. 9).…”

Application of the aza‐Wittig reaction for efficient synthesis of diversely substituted benzo[f]Chromeno[2,3‐d]pyrimidine and benzo[f]chromeno[2,3‐d][1,2,4]triazolopyrimidine derivatives

“…Owing to their broad spectrum of biological activities, chromenes serve as potential antileishmanial [2], antiviral [3], antifungal [4], antimalarial [5], antioxidant [6], antimicrobial [7], anti-HIV [8], and antitumor [9,10] activities. Furthermore, fused chromenes are also privileged scaffolds exhibiting diverse biological activities.…”

Indolyl‐4H‐Chromene Derivatives as Antibacterial Agents: Synthesis, in Vitro and in Silico Studies

“…[2] In the range of heterocyclic compounds, the oxygencontaining 4H-Chromene (4H-1-benzopyran) heterocyclic compounds have attracted particular interest because of their medicinal uses. [3][4][5][6] In Figure 1, a few 4H-chromene compounds having antibacterial importance are shown. The 4H-chromene derivatives, including 2-imino-4H-chromene, [7] 2-hydroxy-1,4naphthoquinone-4H-chromene conjugates, [8] 2-carboxamides-4H-chromene, [9] naphthlamine substituted 4H-chromenes, [10] indole substituted 4H-chromenes, [11] and 3-carboxamides-4Hchromene, [7] showed potential antibacterial activities.…”

“…In the range of heterocyclic compounds, the oxygen‐containing 4 H ‐Chromene (4 H ‐1‐benzopyran) heterocyclic compounds have attracted particular interest because of their medicinal uses [3–6] . In Figure 1, a few 4 H ‐chromene compounds having antibacterial importance are shown.…”