Design, synthesis, characterization and biological evaluation of Thieno[2,3−b]pyridines−chitosan nanocomposites as drug delivery systems for colon targeting

Mansour, Hanaa; Khodair, Ahmed I.; Elsiginy, Samia M.; Elghanam, Amal E.

doi:10.1016/j.carres.2020.107990

Cited by 8 publications

(8 citation statements)

References 35 publications

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“…Overall, the developed DDS constituted of the eFM immobilizing MTZ10-NPs showed activity against both Gram-positive and Gram-negative bacteria, but the sensitivity against E. coli was more pronounced. These findings were also shared by Mansour et al, 55 membrane. 55,56 Another hypothesis suggested was the adsorption of NPs to the cell membrane through electrostatic interactions, which can cause precipitation and coagulation of cytoplasmic proteins followed by bacterial death.…”

Section: Discussionsupporting

confidence: 83%

“…Overall, the developed DDS constituted of the eFM immobilizing MTZ10-NPs showed activity against both Gram-positive and Gram-negative bacteria, but the sensitivity against E. coli was more pronounced. These findings were also shared by Mansour et al , 55 comparing thieno[2,3- b ]pyridine–CH nanocomposites with thieno[2,3- b ]pyridine derivatives. Like the NPs in the present DDS, these nanocomposites also have a positive charge that can bind to the surface of negatively charged bacteria, compromising the normal functions of their membrane.…”

Section: Discussionsupporting

confidence: 76%

“…These findings were also shared by Mansour et al , comparing thieno[2,3- b ]pyridine–CH nanocomposites with thieno[2,3- b ]pyridine derivatives. Like the NPs in the present DDS, these nanocomposites also have a positive charge that can bind to the surface of negatively charged bacteria, compromising the normal functions of their membrane. , Another hypothesis suggested was the adsorption of NPs to the cell membrane through electrostatic interactions, which can cause precipitation and coagulation of cytoplasmic proteins followed by bacterial death. , However, since Gram-negative bacteria present a higher negative charge on cell surfaces than Gram-positive bacteria, a stronger interaction with the NPs may occur, increasing their sensitivity comparing to Gram-positive bacteria. ,, This situation can promote a more evident change in the bacterial morphology of E. coli compared to Gram-positive bacteria in which only DNA strand changes may happen due to the MTZ.…”

Section: Discussionsupporting

confidence: 72%

“…Like the NPs in the present DDS, these nanocomposites also have a positive charge that can bind to the surface of negatively charged bacteria, compromising the normal functions of their membrane. 55 , 56 Another hypothesis suggested was the adsorption of NPs to the cell membrane through electrostatic interactions, which can cause precipitation and coagulation of cytoplasmic proteins followed by bacterial death. 55 , 57 However, since Gram-negative bacteria present a higher negative charge on cell surfaces than Gram-positive bacteria, a stronger interaction with the NPs may occur, increasing their sensitivity comparing to Gram-positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

“… 55 , 56 Another hypothesis suggested was the adsorption of NPs to the cell membrane through electrostatic interactions, which can cause precipitation and coagulation of cytoplasmic proteins followed by bacterial death. 55 , 57 However, since Gram-negative bacteria present a higher negative charge on cell surfaces than Gram-positive bacteria, a stronger interaction with the NPs may occur, increasing their sensitivity comparing to Gram-positive bacteria. 55 , 58 , 59 This situation can promote a more evident change in the bacterial morphology of E. coli compared to Gram-positive bacteria in which only DNA strand changes may happen due to the MTZ.…”

Section: Discussionmentioning

confidence: 99%

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Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection

et al. 2022

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Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. The traditional routes of administration decrease its local effectiveness and present off-site effects. To circumvent such limitations, herein a drug delivery system (DDS) based on MTZ-loaded nanoparticles (NPs) immobilized at the surface of electrospun fibrous meshes is proposed. MTZ at different concentrations (1, 2, 5, and 10 mg mL–1) was loaded into chitosan–sodium tripolyphosphate NPs. The MTZ loaded into NPs at the highest concentration showed a quick release in the first 12 h, followed by a gradual release. This DDS was not toxic to human colonic cells. When tested against different bacterial strains, a significant reduction of Escherichia coli and Staphylococcus aureus was observed, but no effect was found against Enterococcus faecalis. Therefore, this DDS offers high potential to locally prevent the occurrence of infections after colorectal anastomosis.

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Section: Discussionsupporting

confidence: 83%

“…Overall, the developed DDS constituted of the eFM immobilizing MTZ10-NPs showed activity against both Gram-positive and Gram-negative bacteria, but the sensitivity against E. coli was more pronounced. These findings were also shared by Mansour et al , 55 comparing thieno[2,3- b ]pyridine–CH nanocomposites with thieno[2,3- b ]pyridine derivatives. Like the NPs in the present DDS, these nanocomposites also have a positive charge that can bind to the surface of negatively charged bacteria, compromising the normal functions of their membrane.…”

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection

et al. 2022

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Synthesis and characterization of poly (acrylamide‐co‐acrylic acid)/chitosan (derived from fish scales) for controlled release of amoxicillin drug

Sahoo,

Biswal

2024

Polymer Engineering & Sci

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Chitosan (CS) can be extracted from waste fish scales through a series of chemical processes, including demineralization, deproteinization, and deacetylation. The biomaterial poly (acrylamide [AM]‐co‐acrylic acid [AA])/CS is a unique superabsorbent material synthesized through the free radical graft copolymerization method by using AM, AA, and CS powder. During synthesis, ammonium persulfate is used as an initiator, and N, N′‐methylene bisacrylamide is used as a cross‐linker. Scanning electron microscopy and Fourier transform infrared spectroscopy have been studied to know about the morphology and structure of the synthesized superabsorbent materials. The water absorbency of the material continuously increases from day 1 to day 30. The thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG) of the superabsorbent material show adequate thermal stability. The X‐ray diffraction (XRD) analysis indicates that the synthesized biomaterial is virtually amorphous in nature. The percentage of biodegradability increases with time. The encapsulation efficiency of amoxicillin drugs is around 70%, which indicates that the biomaterial is highly efficient for drug release applications. The synthesized novel biomaterial is a low‐cost, eco‐friendly, and thermally stable hydrogel that can be effectively used in drug release applications.Highlights Chitosan (CS)‐based hydrogels are highly pH‐sensitive towards drug release. The biodegradability and swelling behavior of the synthesized biomaterial were studied by adopting a suitable methodology. The novel material formed was characterized by using Fourier transform infrared spectroscopy, TGA, and Scanning electron microscopy. The encapsulation efficiency, kinetic study, and controlled drug release behavior of the amoxicillin drug were studied in solutions of simulated gastric fluid and phosphate‐buffered saline. The material developed in this study shows good performance in controlled drug delivery, and is therefore suitable for manufacturing medical devices used in drug delivery.

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Gold/4-aminopyridine mucoadhesive chitosan nanocomposites as promising nasal drug delivery system for neuroprotection – An ex vivo investigation

Affrald,

Narayan

2024

emergent mater.

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Design, synthesis, characterization and biological evaluation of Thieno[2,3−b]pyridines−chitosan nanocomposites as drug delivery systems for colon targeting

Cited by 8 publications

References 35 publications

Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection

Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection

Synthesis and characterization of poly (acrylamide‐co‐acrylic acid)/chitosan (derived from fish scales) for controlled release of amoxicillin drug

Gold/4-aminopyridine mucoadhesive chitosan nanocomposites as promising nasal drug delivery system for neuroprotection – An ex vivo investigation

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