Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection

Oliveira, Ana Irene Alves de; Araújo, Alexandra M.; Rodrigues, L. C.; Silva, Catarina S.; Reis, Rui L.; Neves, Nuno M.; Leão, Pedro; Martins, Albino

doi:10.1021/acs.biomac.2c00186

Cited by 5 publications

(1 citation statement)

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“…Metronidazole, a poorly water-soluble organic compound, is mainly used as an antibiotic and antigenic insect agent. It can be used to treat colitis caused by antibiotics, and has a good effect on anti-anaerobic protozoa and anti-anaerobic bacteria [76][77][78]. A combination of two Eudragit polymers was designed as the shell section, i.e., the pH-sensitive ES100 and ERL100, to protect the drug from being prematurely dissolved in stomach acid.…”

Section: Introductionmentioning

confidence: 99%

Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole

Wang,

Liu,

Zhu

et al. 2023

Pharmaceutics

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Polymers are the backbone of drug delivery. Electrospinning has greatly enriched the strategies that have been explored for developing novel drug delivery systems using polymers during the past two decades. In this study, four different kinds of polymers, i.e., the water-soluble polymer poly (vinyl alcohol) (PVA), the insoluble polymer poly(ε-caprolactone) (PCL), the insoluble polymer Eudragit RL100 (ERL100) and the pH-sensitive polymer Eudragit S100 (ES100) were successfully converted into types of tri-layer tri-polymer core–shell fibers through bi-fluid coaxial electrospinning. During the coaxial process, the model drug metronidazole (MTD) was loaded into the shell working fluid, which was an emulsion. The micro-formation mechanism of the tri-layer core–shell fibers from the coaxial emulsion electrospinning was proposed. Scanning electron microscope and transmission electron microscope evaluations verified the linear morphology of the resultant fibers and their obvious tri-layer multiple-chamber structures. X-ray diffraction and Fourier transform infrared spectroscopy measurements demonstrated that the drug MTD presented in the fibers in an amorphous state and was compatible with the three polymeric matrices. In vitro dissolution tests verified that the three kinds of polymer could act in a synergistic manner for a prolonged sustained-release profile of MTD in the gut. The drug controlled-release mechanisms were suggested in detail. The protocols reported here pioneer a new route for creating a tri-layer core–shell structure from both aqueous and organic solvents, and a new strategy for developing advanced drug delivery systems with sophisticated drug controlled-release profiles.

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Section: Introductionmentioning

confidence: 99%