Design, Synthesis, and Molecular Docking of Novel Hybrids of Coumarin-Dithiocarbamate Alpha-Glucosidase Inhibitors Targeting Type 2 Diabetes Mellitus

Elahabaadi, Emad; Salarian, Amir Ahmad; Nassireslami, Ehsan

doi:10.1080/10406638.2021.1887295

Cited by 12 publications

(13 citation statements)

References 29 publications

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“…A hydrolyzing enzyme (α-Glucosidase), which is important in the breaking down of starch and carbohydrate to glucose, is usually a target enzyme in the treatment of diabetes mellitus [100,101]. Among the compounds that has been used for the inhibition of this enzyme, coumarin-dithiocarbamate scaffold has proven to be very effective and this has made it a useful compound in the treatment of type 2 diabetes.…”

Section: Application Of Dithiocarbamate Compounds As Enzyme Inhibitormentioning

confidence: 99%

“…Coumarin-dithiocarbamate is a competitive inhibitor of α-glucosidase since it binds to its active site as evidenced by results obtained from molecular docking [101]. Specifically, there is formation of a hydrogen bond between the amino acid (His279) and coumarin moiety [100]. Pyrrolidine dithiocarbamate has also been used as an effective inhibitor of enzymes, specifically the nuclear factor kappa B [102].…”

Section: Application Of Dithiocarbamate Compounds As Enzyme Inhibitormentioning

confidence: 99%

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The Versatility in the Applications of Dithiocarbamates

Ajiboye

Marzouki

Onwudiwe

2022

IJMS

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Dithiocarbamate ligands have the ability to form stable complexes with transition metals, and this chelating ability has been utilized in numerous applications. The complexes have also been used to synthesize other useful compounds. Here, the up-to-date applications of dithiocarbamate ligands and complexes are extensively discussed. Some of these are their use as enzyme inhibitor and treatment of HIV and other diseases. The application as anticancer, antimicrobial, medical imaging and anti-inflammatory agents is examined. Moreover, the application in the industry as vulcanization accelerator, froth flotation collector, antifouling, coatings, lubricant additives and sensors is discussed. The various ways in which they have been employed in synthesis of other compounds are highlighted. Finally, the agricultural uses and remediation of heavy metals via dithiocarbamate compounds are comprehensively discussed.

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Section: Application Of Dithiocarbamate Compounds As Enzyme Inhibitormentioning

confidence: 99%

Section: Application Of Dithiocarbamate Compounds As Enzyme Inhibitormentioning

confidence: 99%

The Versatility in the Applications of Dithiocarbamates

Ajiboye

Marzouki

Onwudiwe

2022

IJMS

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“…3‐(Bromoacetyl)coumarin has gained a reputation as a crucial structural class that is able to take part in the synthesis of diverse bioactive scaffolds [10,11] . Accumulated studies showed a broad range of 3‐(bromoacetyl)coumarin biological activity including anti‐proliferative, antimicrobial, [12] and type 2 diabetes mellitus inhibitory activities [13] . A comprehensive review on different aspects on bi‐heterocyclic coumarins was published by Anand [14] …”

Section: Introductionmentioning

confidence: 99%

3‐Bromoacetylcoumarin, a Crucial Key for Facial Synthesis of Biological Active Compounds

et al. 2022

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Compounds containing the coumarin scaffold are widely used in the pharmaceutical and medicinal industries. The biological activities of coumarin containing derivatives make the attractive for the develop new drugs. Different methods and techniques are developed to synthesize new drugs using coumarin as a starting material. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins containing compounds from 3‐bromoacetylcoumarin. A total of 79 coumarin intermediates and products are reported herein. The different reactions include nucleophilic substitutions, one‐pot and multi‐step synthesis for preparation of coumarin containing compounds through different mechanisms and the outcomes achieved through such reactions are discussed. The prepared compounds showed a range of activities resulting in antifungal, antimicrobial, anti‐inflammatory, antidiabetic and cholinesterase inhibitors. The nucleophilic substitution reactions involving urea related compounds, followed by intramolecular cyclization lead to imidazole and thiazole moieties, which exhibit antibacterial activities. It is hoped that this review provides useful insight for researchers engaged in this field to expand the knowledge gained in this area.

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“…Among these compounds, 3-(bromoacetyl)coumarin 1 and its derivatives are a prominent structural class in the synthesis of various bioactive heterocyclic scaffolds, 17,18 they also are important components in drug discovery on account of their biological activities such as antiproliferative, antimicrobial activities, 19 and are promising inhibitors of type 2 diabetes mellitus. 20 In addition, numerous chemosensors are based on polyfunctional coumarin platforms used to detect multianalyte detection, such as different bioactive elements and various environmental pollutants. 21,22 There is no survey available on the biological and chemical applications achieved since the discovery of 3-(bromoacetyl)coumarins.…”

Section: Introductionmentioning

confidence: 99%