Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents

Abstract

Schematic outline of the most potent compound, benzothiazole bearing amide moiety A07, showing antibacterial activity and its mode of action.

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

“…BTA derivatives have attracted continuing interest because of their varied biological activities viz. anticancer [4], antimicrobial [5], anticonvulsant [6], antiviral [7], antitubercular [8], antimalarial [9], antihelmintic [10], analgesic [11], antiinflammtory [12], antidiabetic [13] and fungicidal activities [14]. Recently, benzothiazole derivatives have been evaluated as potential amyloid-binding diagnostic agents in neurodegenerative disease [15,16], selective fatty acid amide hydrolase inhibitors [17], inhibitors of stearoylcoenzyme A d-9 desaturase [18], LTD4 receptor antagonist [19], orexin receptor antagonist 2 [20], and histamine H 2 antagonists [21].…”

Development of novel apoferritin formulations for antitumour benzothiazoles

“…The benzothiazole structure is important in medicinal chemistry, as derivatives of this scaffold possess anticancer, antibacterial, antiviral, antimalarial, and antifungal activity. From this scaffold, a chemistry‐driven drug discovery project resulted in the development of a wide range of 2‐phenylbenzothiazoles with oxygenated substituents in the phenyl moiety.…”

Synthesis, characterization and X-ray crystal structure of copper(I) complexes of the 2-(2-quinolyl)benzothiazole ligand. Electrochemical and antibacterial studies

“…2-Substituted benzothiazoles have attracted considerable interest due to their diverse biological and pharmaceutical properties, such as antiulcer and antihelminthic [14], antihypertensive [15], anticoagulant [16], antiallergic [17], analgesic [18], anti-inflammatory [19], antimicrobial [20], antivirial [21], antiparasitic [22], anticancer [23] and enzyme inhibitory activity [24]. The increasing applications of metal complexes of 2-substituted benzothiazoles, capable of forming multifunctional complexes, in the area of optoelectronics, the synthesis of fluorogenic enzyme substrates and fluorescent materials are also well recognized [25][26][27].…”