Design, synthesis and insecticidal activity of novel hydrocarbylidene nitrohydrazinecarboximidamides

Xu, Yong; Yang, Dongyan; Zou, Xiang-gao; Rui, Changhui; Zhou, Ziyuan; Ma, Yongqiang; Qin, Z. H.

doi:10.1002/ps.4559

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…A dataset of 31 hydrocarbylidene nitrohydrazine carboximidamide derivatives (Table ) and their insecticidal inhibitory profile (LC 50 ) evaluated on the 3 instar nymph of M. persicae , were collected from the literature . Recent research presumes that these compounds might have the same action mode as guadipyr.…”

Section: Methodsmentioning

confidence: 99%

“…New hydrocarbylidene nitrohydrazine carboximidamides derivatives (guadipyr isomers) were synthesized, as active insecticides against Lipaphis erysimi (turnip aphid) and M. persicae . A suitable flexible alkyl chain at imine point and a Cl‐substituted pyridine ring were found as the most important elements for the insecticidal activity.…”

Section: Introductionmentioning

confidence: 99%

“…This work presents a QSAR study of the insecticidal activity of 31 guadipyr derivatives, active against M. persicae . These compounds were modeled using linear and nonlinear approaches and the best models were further used to find new candidates with potential insecticidal activity.…”

Section: Introductionmentioning

confidence: 99%

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An Approach to Identify New Insecticides Against Myzus Persicae. In silico Study Based on Linear and Non‐linear Regression Techniques

Crisan

Borota

Suzuki

et al. 2019

Molecular Informatics

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This paper is dedicated to Prof. Paola Gramatica on the occasion of her retirement.Abstract: Neonicotinoids are known to have high insecticidal potency, low mammalian toxicity and relatively tough activity for the development of resistance against aphids. A series of guadipyr insecticides, active against Myzus persicae was engaged in silico studies, based on Multiple Linear Regression (MLR), Partial Least Squares regression (PLS), Artificial Neural Networks (ANN), Support Vector Machine (SVM) and Pharmacophore modeling. Robust and predictive models were built using correlations between the insectici-dal profile, expressed by experimental pLC 50 values, and molecular descriptors, calculated from the energy optimized structures. Four new potential insecticides active against Myzus persicae and their predicted pLC 50 toxicity values were reported for the first time. The models presented here can be used as an approach in the screening and prioritization of chemicals in a scientific and regulatory frame and for toxicity prediction.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Approach to Identify New Insecticides Against Myzus Persicae. In silico Study Based on Linear and Non‐linear Regression Techniques

Crisan

Borota

Suzuki

et al. 2019

Molecular Informatics

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“…On the other hand, pyridine is a significant nitrogen‐containing heterocyclic compound, and its derivatives also show a wide spectrum of biological properties, including antifungal, antimicrobial, antitumor, antiviral, herbicidal, and insecticidal activities. Many pyridine derivatives play crucial roles as agrochemicals due to their high activity, low toxicity, and excellent selectivity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antifungal Activity Evaluation of Novel Substituted Pyrimidine‐5‐Carboxamides Bearing the Pyridine Moiety

Wang

Wan

Liu

et al. 2018

J Chinese Chemical Soc

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A series of novel N‐(substituted phenyl/benzyl)‐2‐methylthio‐4‐((pyridin‐3‐ylmethyl)amino)pyrimidine‐5‐carboxamides were synthesized by multistep reactions. The structures of the target compounds were characterized by IR, 1H NMR, 13C NMR, and elemental analysis. Their in vitro antifungal activities against two kinds of plant pathogenic fungi were evaluated by the mycelial growth rate method. The result showed that at the dosage of 100 μg/mL, several of these compounds exhibited moderate activity against Botrytis cinerea with inhibition rates of ~70%, and most compounds (e.g., 5a, 5c, 5e, 5f, and 5h) possessed excellent activity against Sclerotinia Sclerotiorum with more than 90% inhibition rate.

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Design, synthesis, and insecticidal activity of novel 1-alkoxy-2-nitroguanidines

et al. 2018

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Design, synthesis and insecticidal activity of novel hydrocarbylidene nitrohydrazinecarboximidamides

Abstract: Structure-activity relationship analysis indicated that a suitable flexible alkyl chain at the imine point and a Cl-substituted pyridine ring are the most crucial factors affecting the activity. © 2017 Society of Chemical Industry.

Cited by 7 publications

References 14 publications

An Approach to Identify New Insecticides Against Myzus Persicae. In silico Study Based on Linear and Non‐linear Regression Techniques

An Approach to Identify New Insecticides Against Myzus Persicae. In silico Study Based on Linear and Non‐linear Regression Techniques

Synthesis and Antifungal Activity Evaluation of Novel Substituted Pyrimidine‐5‐Carboxamides Bearing the Pyridine Moiety

Design, synthesis, and insecticidal activity of novel 1-alkoxy-2-nitroguanidines

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