Design, synthesis, and insecticidal activity of novel 1-alkoxy-2-nitroguanidines

Abstract

In searching for new insecticidal lead compounds, a series of novel 1-alkoxy-2-nitroguanidine, guadipyr analogues bearing alkoxy groups were designed, synthesized and confirmed by 1H NMR, 13C NMR, high-resolution MS and X-ray diffraction.

Synthesis of Chiral N-Nitro-oxazolidin-2-ones and O-(β-Nitraminoalkyl) Carbamates in Liquefied 1,1,1,2-Tetrafluoroethane Medium

“…6 2-Nitroguanidine derivatives such as clothianidin, dinotefuran, imidacloprid, and thiamethoxam are used as insecticides. 7,8 However, the toxicity of N-nitramines to mammals limits their use in medicine. 1,9 Thus, the synthesis of N-nitro compounds with a minimal side effect on healthy human cells is an important issue that has not yet been fully addressed.…”