“…Among these cationic lipids, carbohydrates-based cationic lipids have been drawn great attention [ 28 , 29 , 30 , 31 ] because carbohydrates and their derivatives (such as, glycans, proteoglycans, glycoproteins, or glycolipids [ 32 , 33 ]) played key roles in a wide range of biological processes including cell-cell informational reception and transmission, cell growth and metastasis, cell adhesion intercellular identification and immunity [ 34 , 35 , 36 ]. Furthermore, lots of studies have shown that glycoside ligand could be acted as a targetable ligand for receptors, such as galactose, mannose, glucose and hyaluronic acid [ 30 , 31 , 37 , 38 , 39 ], which overexpressed in the surface of cancer cells. Therefore, carbohydrates may be conjugated in targeted gene delivery system with high transfer efficiency and safety.…”