Design, synthesis andin vitrocytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors

Abstract

In the pursuit of finding a potential and effective chemotherapeutic agent, a series of 2-(3-(indol-3-yl)-pyrazol-5-yl)imino)thiazolidin-4-ones was designed and synthesized, conjoining salient pharmacophoric properties directing prominent cytotoxicity. The in vitro cytotoxicity...