Design, synthesis, and herbicidal activity of pyrazole benzophenone derivatives

Abstract

Design of pyrazole benzophenones as potent HPPD inhibitors with excellent herbicidal activities.

Crystal structure of 5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-(2,2-dichloroacetyl)-3,4-dihydro-2 H-benzo[b][1,4]oxazine-7-carboxylate, C19H19Cl2NO5

“…As an important enzyme correlated to the pigment synthesis and tyrosine catabolism in most organisms, HPPD is important in agricultural areas [14]. A large number of HPPD inhibitors have been discovered, researched and applied to control weed in the field of agrochemicals in recent several decades [15]. Based on our previous efforts to find novel HPPD-inhibiting compounds [16], herein we reported the synthesis and the crystal structure of substituted benzoxazine-cyclohexanedione.…”

Crystal structure of (4-ethoxynaphthalen-1-yl)(furan-2-yl)methanone, C17H14O3

“…Great efforts have been devoted to synthesis of the attractive target diaryl ketones skeleton due to its prevalent biological activity [8]. In our continuing effort to search for novel agrochemicals [9][10][11], herein we reported the synthesis and crystal structure of substituted diaryl ketone via alkylation and Friedel-Crafts acylation reactions.…”

Synthesis and herbicidal activity of novel pyrazole aromatic ketone analogs as HPPD inhibitor

“…Inhibition of HPPD causes bleaching by blocking PDS activity due to loss of PQ synthesis. So far, three kinds of HPPD‐type herbicides have been discovered: triketones, pyrazoles and isoxazoles (Fig. ).…”