Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

Bali, Alka; Bansal, Yogita; Sugumaran, Manickam; Saggu, Jatinder Singh; Balakumar, Pitchai; Kaur, Gurpreet; Bansal, Gulshan; Sharma, Ajay; Singh, Manjeet

doi:10.1016/j.bmcl.2005.05.054

Cited by 44 publications

(10 citation statements)

References 14 publications

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“…After stirring for 30 min at room temperature, triphenylmethyl chloride (2.79 g, 10 mmol) was added and the mixture was stirred for another 3-4 h. After the evaporation of the solvent, the residue was dissolved in ethyl acetate, washed with solution of NaOH (1N) and dried over anhydrous magnesium sulfate. The crude product was purified by Al 2 (9). This was prepared according to a modified method.…”

Section: -Triphenylmethyl-2-(4 0 -Methylbiphenyl-2-yl)-1h-imidazole mentioning

confidence: 99%

“…1,2 This stimulated many researchers toward designing drugs to block the effects of AngII either by inhibiting the angiotensin-converting enzyme (ACE) or renin or by blocking the AngII receptors. [3][4][5][6][7][8][9][10] AngII receptor antagonists have proved to lower blood pressure effectively, 11 and they are better tolerated than other classes of drugs. 12,13 Losartan, 14,15 the protypical agent of this category, was served as lead for the development of newer AngII receptor antagonists.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring

Guo

Shi

Wang

et al. 2008

Bioorganic & Medicinal Chemistry

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Section: -Triphenylmethyl-2-(4 0 -Methylbiphenyl-2-yl)-1h-imidazole mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring

Guo

Shi

Wang

et al. 2008

Bioorganic & Medicinal Chemistry

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“…16 Aryl or alkyl carboxamide benzimidazole derivatives possess potent antihypertensive activity by inhibiting angiotensine II. 17 Nitro benzimidazoles were reported to possess antitumor activity. 18 Substitution of carboxylic acid at 2 positions is a dominant structural requirement for anti inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some New Class of Chromenoimidazole Derivatives as Probable Anti Cancer Agents

2017

RJC

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A new series of compounds with benzimidazole moiety fused pyran ring derivatives were prepared by a simple chemical methodology. Here we have designed and reported a one pot condensation of 6-hydroxy-5-formyl benzimidazole with different N substituted cyano acetamide derivatives to get novel chromeno-benzimidazole molecules which were characterized by different analytical tools and docking study of these compounds against a lung cancer target protein(PDB Id : 3POZ). Most of the compounds exhibited good potency in inhibiting the cancer protein.

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“…1) has been designed and synthesized earlier in our laboratory and it is found more active than candesartan. 9 Another series of 5-alkylcarboxamido (−NHCOR) benzimidazole derivatives has also been designed and synthesized in our laboratory 10 from which 5-acetamido analog 2 (Fig. 1) is found equipotent to candesartan.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists

Kaur

Bansal

et al. 2008

Bioorganic & Medicinal Chemistry

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A series of 5-alkylsulfamoyl benzimidazole derivatives have been designed and synthesized as novel angiotensin II (Ang II) receptor antagonists. The compounds have been evaluated for in vitro Ang II antagonism and for in vivo antihypertensive activity on isolated rat aortic ring and desoxycortisone acetate induced hypertensive rats, respectively. The activity is found related to size of alkyl group. The maximum activity is observed with a compact and bulky alkyl group like tert-butyl and cyclohexyl. The compounds 4g and 4h have shown promising both in vitro and in vivo activities. A receptor binding model is also proposed on the basis on the basis of structure–activity relationship in this study.

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Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

Cited by 44 publications

References 14 publications

Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring

Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring

Synthesis and Biological Evaluation of Some New Class of Chromenoimidazole Derivatives as Probable Anti Cancer Agents

Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists

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