Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3K α inhibitors

Synthesis, Biological Evaluation, Molecular Docking and ADME Profiling of Methylpiperidin‐4‐ylphenyl‐nicotinamide Derivatives

“…To a stirred solution of 5‐Methylpyridin‐2‐amine [25] 2 (1 g, 9.25 mmol, 1.0 eq.) in acetonitrile (20 mL) was added N‐Bromo succinimide (0.05 g, 7.4 mmol, and 0.8 eq.)…”

“…Modifying the solvent system to DME:EtOH: Water (7 : 2 : 1) and heating the reaction mixture at 100-120 °C for 16 h in conventional heating (Table 1, entry 3) and 120 °C (1.5 h) in microwave irradiation (Table 2, entry 3) resulted in similar and good yields. Same condition followed for synthesis [25][26][27][28] of remaining molecules (9 c-n) (Table 3 and Figure 4).…”

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

“…The NCI-USA antitumor assessment 39 , MTT viability 40 , 41 , VEGFR-2 inhibition 42 , 43 , CA I, II, and IX inhibition studies 44–47 , cell cycle analysis and annexin V-FITC apoptosis assay 48 , 49 were all carried out as previously published in the current study. The supplementary data included descriptions of every experimental technique.…”

Base‐Induced Annulation of Glycal‐Derived α‐iodopyranone with 2‐Aminopyrimidinones: Access to Chiral Imidazopyrimidinones

“…[4] For instance, they can inhibit specific kinases involved in cell signalling, preventing the activation of downstream targets responsible for promoting cancer cell growth and survival. [5] Certain compounds derived from imidazopyridine exhibit anti-inflammatory characteristics that can control the inflammation associated with cancer and the mitigation of complications related to tumors. [6] Moreover, imidazopyridines have been investigated for their potential as anti-angiogenic agents, inhibiting the development of blood vessels responsible for delivering nutrients to tumours and thus impeding their growth.…”

“…Furthermore, imidazopyridine compounds have demonstrated the ability to inhibit the activity of enzymes and proteins that are essential for cancer cell survival [4] . For instance, they can inhibit specific kinases involved in cell signalling, preventing the activation of downstream targets responsible for promoting cancer cell growth and survival [5] . Certain compounds derived from imidazopyridine exhibit anti‐inflammatory characteristics that can control the inflammation associated with cancer and the mitigation of complications related to tumors [6] .…”