Base‐Induced Annulation of Glycal‐Derived α‐iodopyranone with 2‐Aminopyrimidinones: Access to Chiral Imidazopyrimidinones

Abstract

A simple, environmentally benign and catalyst‐free method for the synthesis of chirally enriched imidazo[1,2‐a]pyrimidinone glycohybrids has been successfully developed. The protocol is based on a base‐induced annulation of α‐iodo‐pyranone with Michael addition of 2‐aminopyrimidinones followed by intramolecular nucleophilic substitution reaction. The privilege of this method includes mild reaction conditions, eco‐friendly solvent and a transition metal‐free approach. Moreover, using straightforward simple methods, this reaction method exhibits a broad range of substrate scope and remarkable tolerance toward various functional groups.