Design, synthesis and biological evaluation of dihydrofurocoumarin derivatives as potent neuraminidase inhibitors

Zhong, Zhi Jian; Li, Cheng; Pang, Wan; Zheng, Xue Song; Fu, Shi Kai

doi:10.1016/j.bmcl.2021.127839

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…Compound 109 was the most active aurone found, showing a higher affinity for IAV neuraminidase (IC 50 = 20 nM) than the reference oseltamivir carboxylate (IC 50 = 40 nM). 158 Some aurones were also tested in anti-HIV assays. First, Gao et al performed an antiviral evaluation in their phytochemical report involving five natural aurone analogues.…”

Section: Neurochemical Activities Inhibition Of Monoamine Oxidases (M...mentioning

confidence: 99%

“…The approach was overall successful, as several aurone analogues presented IC 50 values below 50 nM in the series. Compound 109 was the most active aurone found, showing a higher affinity for IAV neuraminidase (IC 50 = 20 nM) than the reference oseltamivir carboxylate (IC 50 = 40 nM) . Some aurones were also tested in anti-HIV assays.…”

Section: Biological Activities Of Hemiindigoidsmentioning

confidence: 99%

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Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives

et al. 2022

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Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same aromatic hydrocarbon backbone as well as promising biological and optical properties. The encouraging therapeutic potential of these scaffolds has been unraveled by many studies over the past years and uncovered representants with inspiring pharmacophoric features such as the acetylcholinesterase inhibitor donezepil and the tubulin polymerization inhibitor indanocine. In this review, we summarize the last advances in the medicinal potential of hemiindigoids, with a special attention to molecular design, structure–activity relationship, ligand-target interactions, and mechanistic explanations covering their effects. As their strong fluorogenic potential and photoswitch behavior recently started to be highlighted and explored in biology, giving rise to the development of novel fluorescent probes and photopharmacological agents, we also discuss these properties in a medicinal chemistry perspective.

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Section: Neurochemical Activities Inhibition Of Monoamine Oxidases (M...mentioning

confidence: 99%

Section: Biological Activities Of Hemiindigoidsmentioning

confidence: 99%

Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives

et al. 2022

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“…For this family of dihydrofurocoumarin derivates, the 430-and 150-cavities are crucial in defining the actions against NA. [71] Xiao et al designed, synthesised and tested a series of 4thiazolinone derivatives for their ability to inhibit influenza H1 N1 NA. According to their findings, the majority of the target compounds had NA inhibitory activity that was between moderate to good.…”

Section: Anti-influenza Small Moleculementioning

confidence: 99%

Recent Efforts in Identification of Privileged Scaffolds as Antiviral Agents

Yadav,

Singh,

Sharma

et al. 2023

Chemistry & Biodiversity

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Viral infections are the most important health concern nowdays to mankind, which is unexpectedly increasing the health complications and fatality rate worldwide. The recent viral infection outbreak develops a pressing need for small molecules that can be quickly deployed for the control/treatment of re‐emerging or new emerging viral infections. Numerous viruses, including the human immunodeficiency virus (HIV), hepatitis, influenza, SARS‐CoV‐1, SARS‐CoV‐2, and others are still challanging due to emerging resistant to known drugs. Therefore, there is alway a need to search for new antiviral small molecules who can combat viral infection with new mode of action. This review highlighted rececnt progress on development of new antiviral molecule based on natural product inspired scafflods. Herein, structure activity relationship of the FDA approved drugs alongwith the molecular docking studies of selected compounds have been discussed against several target proteins. The findings of new small molecules as neuraminidase inhibtors, other than known drug scafflods, Anti‐HIV and SARS‐CoV are incorporated in this review paper.

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“…The influenza A virus H5N1 neuraminidase was used as the target protein, and the PDB ID was 2HU0, which was obtained from the protein database (https://www.rcsb.org/pdb/). 20 Table S2 (ESI †) lists the X-ray coordinates of 2HU0. Some preparations such as removing water, adding hydrogens, and modifying the protein structure were needed before the docking analysis.…”

Section: Virtual Screeningmentioning

confidence: 99%

Design, synthesis and biological evaluation of oxalamide derivatives as potent neuraminidase inhibitors

et al. 2022

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Design, synthesis and biological evaluation of dihydrofurocoumarin derivatives as potent neuraminidase inhibitors

Cited by 11 publications

References 34 publications

Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives

Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives

Recent Efforts in Identification of Privileged Scaffolds as Antiviral Agents

Design, synthesis and biological evaluation of oxalamide derivatives as potent neuraminidase inhibitors

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