Recent Efforts in Identification of Privileged Scaffolds as Antiviral Agents

Abstract

Viral infections are the most important health concern nowdays to mankind, which is unexpectedly increasing the health complications and fatality rate worldwide. The recent viral infection outbreak develops a pressing need for small molecules that can be quickly deployed for the control/treatment of re‐emerging or new emerging viral infections. Numerous viruses, including the human immunodeficiency virus (HIV), hepatitis, influenza, SARS‐CoV‐1, SARS‐CoV‐2, and others are still challanging due to emerging resistant to known drugs. Therefore, there is alway a need to search for new antiviral small molecules who can combat viral infection with new mode of action. This review highlighted rececnt progress on development of new antiviral molecule based on natural product inspired scafflods. Herein, structure activity relationship of the FDA approved drugs alongwith the molecular docking studies of selected compounds have been discussed against several target proteins. The findings of new small molecules as neuraminidase inhibtors, other than known drug scafflods, Anti‐HIV and SARS‐CoV are incorporated in this review paper.