Design, synthesis and biological evaluation of peptide dendrimers with wound healing promoting activity

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

“…368 They have been widely reported as drug delivery agents, antiviral agents, synthetic vaccines, and as agents for wound treatment. [368][369][370][371][372][373][374][375][376] Antimicrobial peptide dendrimers (AMPDs) have recently attracted considerable attention as a novel class of synthetic AMPs, and the scaffold of a PD offers several advantages compared to linear peptides including greater stability, multivalency and a reduced risk of peptide aggregation during synthesis. This type of scaffold can also be easily modified.…”

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

“…Peptide dendrimers and dendritic peptide polymers (Fig. 1) have also been introduced into wound management by our group 95,[146][147][148] and others [149][150][151][152][153][154] and exhibited exceptional antibacterial and adhesive performance attributed to their highly symmetrical structure with multiple peripheral reactive groups. Precise design of dendrimers allows fine control of molecular structure and composition while providing multiple functions 114,149 in wound repairing such as considerable mechanical enhancement for open wound contraction, 95 immunomodulation, 148,153 and bacteria elimination, 95,154 due to the multivalent effect of dendrimers (Fig.…”

Exploring Dendrimer Nanoparticles for Chronic Wound Healing

“…Deng and co-workers synthesized dendrimer peptides on three different lysine cores, ranging from single lysine to five lysine residues, attached to the short peptide Ac-PHSRN-NH2, which originates from the cell binding site of fibronectin ( 24 ). They found that treating diabetic wounds with different fibronectin derivatives of peptide dendrimers provided faster re-epithelialization, increased contraction of dermal wounds, and accelerated wound healing in diabetic mice ( 24 ). The group surmised results from their study points to wound closure activity being closely linked to dendrimer branching.…”