Exploring Dendrimer Nanoparticles for Chronic Wound Healing

Tetteh-Quarshie, Samuel; Blough, Eric R.; Jones, Cynthia C.

doi:10.3389/fmedt.2021.661421

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Nanocarriers are perfect for inducing cell-to-cell contacts, cell proliferation, vascularization, cell signaling, and biomolecule synthesis, all of which are required for efficient wound healing. Additionally, nanocarriers have the ability to deliver one or more therapeutic molecules, including growth factors, nucleic acids, antibiotics, and antioxidants, to the target area in a sustained way [ 67 ].…”

Section: Curcumin-loaded Delivery Systems For Wound Healingmentioning

confidence: 99%

Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review

et al. 2022

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Curcumin or turmeric is the active constituent of Curcuma longa L. It has marvelous medicinal applications in many diseases. When the skin integrity is compromised due to either acute or chronic wounds, the body initiates several steps leading to tissue healing and skin barrier function restoration. Curcumin has very strong antibacterial and antifungal activities with powerful wound healing ability owing to its antioxidant activity. Nevertheless, its poor oral bioavailability, low water solubility and rapid metabolism limit its medical use. Tailoring suitable drug delivery systems for carrying curcumin improves its pharmaceutical and pharmacological effects. This review summarizes the most recent reported curcumin-loaded delivery systems for wound healing purposes, chiefly hydrogels, films, wafers, and sponges. In addition, curcumin nanoformulations such as nanohydrogels, nanoparticles and nanofibers are also presented, which offer better solubility, bioavailability, and sustained release to augment curcumin wound healing effects through stimulating the different healing phases by the aid of the small carrier.

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Section: Curcumin-loaded Delivery Systems For Wound Healingmentioning

confidence: 99%

Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review

et al. 2022

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“…Dendrimers are made of polymers with branched treelike structures, in which the mass, size, shape, and surface chemistry can be highly controlled . They can be used as therapeutic nanocarriers , and as excipients …”

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confidence: 99%

“…189 Dendrimers are made of polymers with branched treelike structures, in which the mass, size, shape, and surface chemistry can be highly controlled. 190 They can be used as therapeutic nanocarriers 191,192 and as excipients. 193 Polymeric-based nanogels appear as a powerful tool for successful scaffold development, would-healing treatment, or cancer treatment with minimally invasive interventions.…”

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confidence: 99%

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

et al. 2022

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Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations and technophobic demands must be counterbalanced in parallel. Some of the burning issues today are the following: (1) Where is nano today? (2) How good are the communication and investment networks between academia/research and governments? (3) Is there any spotlight application for nanotechnology? Nanomedicine is a particular arm of nanotechnology within the healthcare landscape, focused on diagnosis, treatment, and monitoring of emerging (such as coronavirus disease 2019, COVID-19) and contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, and cancer) diseases. However, it may only represent the bright side of the coin. In fact, in the recent past, the concept of nanotoxicology has emerged to address the dark shadows of nanomedicine. The nanomedicine field requires more nanotoxicological studies to identify undesirable effects and guarantee safety. Here, we provide an overall perspective on nanomedicine and nanotoxicology as central pieces of the giant puzzle of nanotechnology. First, the impact of nanotechnology on education and research is highlighted, followed by market trends and scientific output tendencies. In the next section, the nanomedicine and nanotoxicology dilemma is addressed through the interplay of in silico, in vitro, and in vivo models with the support of omics and microfluidic approaches. Lastly, a reflection on the regulatory issues and clinical trials is provided. Finally, some conclusions and future perspectives are proposed for a clearer and safer translation of nanomedicines from the bench to the bedside.

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