Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis

Huang, He; Yao, Yongfang; Hou, Guodong; Zhao, Cui; Qin, Jianwu; Zhang, Yixin; Duan, Yongtao; Song, Chuanjun; Chang, Junbiao

doi:10.1016/j.ejmech.2021.113708

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…Previous studies have confirmed that the anticancer activity of some microtubule inhibitors targeting the colchicine site in vitro and in vivo is mediated by antiangiogenesis ( 11 ). The anticancer activity of tanshinone IIA analogs is reflected in their inhibition of tumor vascular endothelial cell proliferation, migration, and tube formation ( 29 ). However, it is still blank about the antitumor angiogenesis effect of SMART and its analogues so far.…”

Section: Discussionmentioning

confidence: 99%

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers

Huang

Zhou

et al. 2022

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers

Huang

Zhou

et al. 2022

Journal of Biological Chemistry

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“…Meanwhile, it has been reported that STS could relieve angiogenesis during cancer progression (Huang et al. 2021 ; Zeng et al. 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma via mediation of miR-874/eEF-2K/TG2 axis

Wang

Zou

et al. 2023

Pharmaceutical Biology

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Context Sodium tanshinone IIA sulphate (STS) is a product originated from Salvia miltiorrhiza Bunge [Lamiaceae], which exerts an antitumour effect. However, the role of STS on lung adenocarcinoma (LUAD) remains unexplored. Objective Our study explores the effect and mechanism of STS against LUAD. Materials and methods LUAD cells were treated with 100 μM STS for 24 h and control group cells were cultured under normal medium conditions. Functionally, the viability, migration, invasion and angiogenesis of LUAD cells were examined by MTT, wound healing, transwell and tube formation assay, respectively. Moreover, cells were transvected with different transfection plasmids. Dual luciferase reporter and RNA immunoprecipitation (RIP) assays were used to verify the relationship between miR-874 and eEF-2K. Results STS significantly decreased the viability (40–50% reduction), migration (migration rate of A549 cells from 0.67 to 0.28, H1299 cells from 0.71 to 0.41), invasion (invasion numbers of A549 cells from 172 to 55, H1299 cells from 188 to 35) and angiogenesis (80-90% reduction) of LUAD cells. Downregulation of miR-874 partially abolished the antitumour effect of STS. EEF-2K was identified to be the target of miR-874, and its downregulation markedly abolished the effects of miR-874 downregulation on tumourigenesis of LUAD. Moreover, silencing of TG2 abrogated eEF-2K-induced progression of LUAD. Discussion and Conclusions STS attenuated the tumourigenesis of LUAD through the mediation of the miR-874/eEF-2K/TG2 axis. STS is a promising drug to fight against lung cancer, which might effectively reverse drug resistance when combined with classical anticancer drugs.

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“…Natural products such as berberine (Tong et al, 2021), quercetin (Zhou et al, 2020), and dihydromyricetin (DMY) (Wang Z et al, 2020) can reverse the multidrug resistance of tumor cells. Beta-escin (Lengyel et al, 2021) and icaritin (Huang H et al, 2021) exert anticancer effects by regulating and improving the tumor microenvironment. A novel strategy in systematic pharmacology integrates active compound screening, target prediction, network pharmacology analysis, and oncoimmune phylogeny to identify the potential active components of natural products.…”

Section: Discussionmentioning

confidence: 99%

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Shen

2022

Front. Pharmacol.

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Background: The patent literature contains a large amount of information on the internal state of current industrial technologies that are not available in other literature studies. Scientific articles are the direct achievements of theoretical research in this field and can reveal how current theories in basic research have developed. In this study, the progress and status of natural anticancer products in this field were summarized, and the research hotspots were explored through the analysis of the relevant patent literature and scientific articles.Methods: Patent data were retrieved from the incoPat patent retrieval database, and paper data were retrieved from the Web of Science core set and PubMed. GraphPad Prism 8, Microsoft Excel 2010, and CiteSpace 5.8.R3 were used to perform visual processing. The analyzed patent literature includes the patent applicant type, country (or region), and technical subject. The analyzed scientific article includes academic groups, subject areas, keyword clustering, and burst detection.Results: A total of 20,435 patent families and 38,746 articles were collected by 4 January 2022. At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, Theranekron D6, and gaillardin; 2) topoisomerase inhibitors such as camptothecins, scaffold-hopped flavones, podophyllotoxin, oxocrebanine, and evodiamine derivatives; 3) telomerase inhibitors such as camptothecin and isoquinoline alkaloids of Chelidonium majus, amentoflavone, and emodin; 4) microtubule inhibitors such as kolaflavanone, tanshinone IIA analog, eugenol, and millepachine; 5) immunomodulators such as fucoidan, myricetin, bergapten, and atractylenolide I; 6) tumor microenvironment regulators such as beta-escin and icaritin; 7) multidrug resistance reversal agents such as berberine, quercetin, and dihydromyricetin; and 8) antiangiogenic and antimetastatic agents such as epigallocatechin-3-gallate, lupeol, ononin, and saikosaponin A.Conclusion: Anticancer natural product technology was introduced earlier, but the later development momentum was insufficient. In addition, scientific research activities are relatively closed, and technical exchanges need to be strengthened. Currently, the development of medicinal plants and the research on the anticancer mechanism of natural active products are still research hotspots, especially those related to immune checkpoints, essential oils, and metastatic cancer. Theories of traditional Chinese medicine (TCM), such as “restraining excessiveness to acquire harmony,” “same treatment for different diseases,” “Meridian induction theory,” and “Fuzheng Quxie,” have important guiding significance to the research of anticancer mechanisms and the development of new drugs and can provide new ideas for this process.Systematic Review Registration: [https://sourceforge.net/projects/citespace/], identifier [000755430500001].

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Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis

Cited by 10 publications

References 34 publications

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers

A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancers

Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma via mediation of miR-874/eEF-2K/TG2 axis

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

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