“…For instance, sila-isosteres exhibit better stability, lipophilicity, bioavailability, efficiency, and safety compared with their analogs. Generally, the strategy of bio-sila-isosterism has promising outcomes, and Si-containing structures can become highly effective agents against severe diseases, such as hypertension, diabetes mellitus, HIV, and cancer [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”