Background:
Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.
Introduction:
In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.
Methods:
Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.
Results:
These studies highlight the importance of molecular docking.
Conclusion:
Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.