Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles

Synthesis and biological activities of novel trifluoromethylpyridine amide derivatives containing sulfur moieties

“…It can be found in many secondary metabolites in living organisms, and exits also in many bio-active compounds ( Fig. 1) with broaden biological activities, [7][8][9][10][11][12][13][14] especially using for anticancer, [15][16][17][18] anti-HIV, 19,20 and treating acid-related disorder, 21 and also using for the inhibitors of topoisomerase 1, 22 anhydrase II, 23 mutated B-Raf, 24,25 cyclooxygenase-2. 26,27 Particularly, compounds containing thioether, sulfone or sulfoxide moieties could exhibit signicantly anti-bacterial, [28][29][30][31][32] anti-fungal, 33,34 herbicidal 35 and insecticidal 36,37 activities for crop protection.…”

Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

“…Indoles and benzimidazole are gaining attention because of their anti-tumour and anti-estrogenic effects. Karadayi and associates 126 in 2020 reported novel indole-benzimidazole derivatives. They synthesised a set of indole-benzimidazoles having benzene sulfonyl structure and evaluated to assess their anti-proliferative activity.…”

Indole Derived Anticancer Agents

“…When R 1 as p‐fluorobenzyl and R 2 as bromo, the lead compound showed potent anticancer effects and moderate structural affinity to ER. Compounds 21 and 22 (Figure 8) can modulate ER target gene expression in a dose‐dependent manner as compared to tivozanib (standard drug) [44] …”