No abstract

Amidoalkyl-2-naphthol is one of the vital synthetic intermediates which occupy an imperative position in medicinal chemistry due to its amazing biological, pharmacological as well as industrial and synthetic applications. Owing to its diverse pharmaceutical activities, hundreds of scientific literature are available, signifying the efficient synthesis of this intermediate using various catalysts. Most of these literature methods suffer from low yield and harsh reaction conditions that further ignited the researcher to explore for another green catalyst and fresh methodologies. This review summarizes the last five years progress in the catalytic synthesis of 1-amidoalkyl-2-naphthols using various heterogenous, homogenous and nanocatalysts along with their mechanism of action. Various advantages like green synthesis, atom economy, clean reaction profile and catalyst recovery are discussed which facilitate the scientist to probe and stimulate the study on this scaffold. In the end, the catalysts and reactions condition are organized into the tables for swift at a glance understanding of different catalysts used with their yield and time taken for the synthesis.

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2001 ring closure reactions ring closure reactions O 0130 41 -057 Synthesis and Antimicrobial Study of Heterocyclyl Substituted s-Triazoles, 1,3,4-Thiadiazoles, Oxadiazoles and Related Heterocycles. -The title compound (Vd) is active against S. aureus, S. dysenteriae, S. typhi and P. mirabilis. Compound (IVb) is active against K. pneumoniae. -(DHIMAN, A. M.; WADODKAR, K. N.; PATIL, S. D.; Indian J. Chem., Sect.

Aim: To develop controlled-release tablets based on aminated starch. Materials & methods: Aminated starch was characterized with Fourier transform infrared and x-ray diffraction. Thermogravimetric analysis confirmed the preferential oxidation of crystalline region of starch. Results: The tablets achieved an initial fast release of fenamates, which slows down after 12 h. Drug release was not completed in the simulated intestinal media, which may be due to the stability of imine bond in aminated starch at weakly acidic pH. Drug release was completed in simulated acidic media due to the hydrolysis of imine functionality at strongly acidic pH. Conclusion: Aminated starch with an imine functionality may serve as intestine targeted, controlled drug-delivery system. Mucoadhesive potential of tablets further supports this observation.