Design optimization of capillary-driven micromixer with square-wave microchannel for blood plasma mixing

Kuo, Jimmy; Liao, Hong-Song; Li, Xiangming

doi:10.1007/s00542-015-2722-1

Cited by 23 publications

(12 citation statements)

References 37 publications

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“…Mixed microfluidic chips as a platform for glucose assays [9], carcinoembryonic antigen detection [10], and mixer of blood plasma [11] are commonly based on the chaotic motion within the liquid irregularly causing random variation of velocity and pressure in time and space. A riotous shift in weather conditions can be produced by blending the stream for blood plasma mixing [12], and this is exceptionally successful at low Reynolds numbers [12] because of the subsequent parting, extending, collapsing, and separating of the species streams [13].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Numerical Simulation of Micromixing of Particles and Fluids with Galloping Cylinder

Abdelmalek

Jamalabadi

2020

Symmetry

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Micromixers are significant segments inside miniaturized scale biomedical frameworks. Numerical investigation of the effects of galloping cylinder characteristics inside a microchannel Newtonian, incompressible fluid in nonstationary condition is performed. Governing equations of the system include the continuity equation, and Navier–Stokes equations are solved within a moving mesh domain. The symmetry of laminar entering the channel is broken by the self-sustained motion of the cylinder. A parameter study on the amplitude and frequency of passive moving cylinder on the mixing of tiny particles in the fluid is performed. The results show a significant increase to the index of mixing uses of the galloping body in biomedical frameworks in the course of micro-electromechanical systems (MEMS) devices.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Numerical Simulation of Micromixing of Particles and Fluids with Galloping Cylinder

Abdelmalek

Jamalabadi

2020

Symmetry

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“…To examine the mixing performance of the two micromixers, a variance‐based method is used to compute the mixing index in order to quantify the mixing process on a plane as used by various researchers 29–32 . The mixing index is given by

italicMi = ((), 1 - \sqrt{\frac{σ^{2}}{σ_{\max}^{2}}}) \times 100,

σ^{2} = \frac{1}{n} \sum_{i = 1}^{n} {(c_{i} - c_{italicavg})}^{2},

where σ 2 is the actual variance in the mass fraction of the fluid component and

σ_{\max}^{2}

represents the maximum variance.…”

Section: Numerical Modelingmentioning

confidence: 99%

“…Serpentine micromixer displayed better mixing results for all the wide range of mass flow rates that were considered in the study. Besides, vast literature is available discussing the flow and mixing process for non‐Newtonian blood 30–35 …”

Section: Introductionmentioning

confidence: 99%

Numerical investigation of the performance of 3D‐helical passive micromixer with Newtonian fluid and non‐Newtonian fluid blood

Tokas

Zunaid

Ansari

2020

Asia-Pacific J Chem Eng

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Mixing at microscales is purely governed by the diffusion mass transport phenomenon, which is a time‐consuming process requiring a prolonged length of the microchannel to obtain desired results. The present study proposes a novel three‐dimensional helical micromixer (TDHM) with a rectangular cross‐section to achieve splendid mixing performance within a short distance contrary to the simple T‐micromixer (STM). A thorough numerical investigation of mixing performance and fluid flow patterns has been conducted using the continuity, species transport, and the Navier–Stokes equations with Newtonian and non‐Newtonian fluid at a wide range of Reynolds number (0.2–320) and mass flow rate (0.00005–0.091 kg/h), respectively. Blood is selected as the non‐Newtonian fluid, and its rheological characteristics are numerically captured by implementing the Carreau–Yasuda model, whereas water is used to study mixing with the Newtonian fluid. At Re = 2, the mixing index of TDHM is 40. 5% more than that of the STM with water as the working fluid, whereas for blood, it is 34.3%, and thus, it was concluded that the TDHM gives much better performance at much less axial distance than that of the STM at all values of the Reynolds number and flow rates considered in the study. Therefore, TDHM can be utilized for various biomedical, chemical, and biochemical applications.

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“…Square-wave mixing units for blood plasma mixing 42 The mixing index was reported as 76% for the optimized one…”

Section: The "Hybrid" Micromixer With Muromentioning

confidence: 99%

A hybrid micromixer with planar mixing units

et al. 2018

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Design optimization of capillary-driven micromixer with square-wave microchannel for blood plasma mixing

Cited by 23 publications

References 37 publications

RETRACTED: Numerical Simulation of Micromixing of Particles and Fluids with Galloping Cylinder

RETRACTED: Numerical Simulation of Micromixing of Particles and Fluids with Galloping Cylinder

Numerical investigation of the performance of 3D‐helical passive micromixer with Newtonian fluid and non‐Newtonian fluid blood

A hybrid micromixer with planar mixing units

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