Design, optimization, and in-vivo performance of glipizide-loaded O-carboxymethyl chitosan nanoparticles in insulin resistant/type 2 diabetic rat model

El-Dakroury, Walaa A.; Amin, Mohamed M.

doi:10.1016/j.jddst.2022.104040

Cited by 13 publications

(5 citation statements)

References 71 publications

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“…GPZ-O-CMC NPs significantly increased serum glucose, insulin, lipid profile (3-4 folds), oxidative stress markers (2-3 folds), and inflammatory cytokines (2.5-3.5 folds) in rats. Based on in vitro release studies, GPZ-O-CMC NPs released 22.5% of GPZ within two hours and 62.5% within 34 h. In vivo studies revealed that GPZ-O-CMCNPs significantly improved T2D-related biomarkers in comparison with pure and marketed GPZ, confirming their potential as a T2D treatment [117].…”

Section: Sulfonylureas and Glinidesmentioning

confidence: 83%

“…Treatment of T2D consists of lifestyle changes (weight loss, diet, and exercise) with the prescription of metformin, an antidiabetic class of biguanides that is the main first-line oral drug of choice in the management of diabetes [117,122,123]. Metformin is an insulin sensitizer drug that is currently the most prescribed antidiabetic medicine worldwide for T2D [124].…”

Section: Biguanidesmentioning

confidence: 99%

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Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes

et al. 2023

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Diabetes poses major economic, social, and public health challenges in all countries worldwide. Besides cardiovascular disease and microangiopathy, diabetes is a leading cause of foot ulcers and lower limb amputations. With the continued rise of diabetes prevalence, it is expected that the future burden of diabetes complications, early mortality, and disabilities will increase. The diabetes epidemic is partly caused by the current lack of clinical imaging diagnostic tools, the timely monitoring of insulin secretion and insulin-expressing cell mass (beta (β)-cells), and the lack of patients’ adherence to treatment, because some drugs are not tolerated or invasively administrated. In addition to this, there is a lack of efficient topical treatment capable of stopping the progression of disabilities, in particular for treating foot ulcers. In this context, polymer-based nanostructures garnered significant interest due to their tunable physicochemical characteristics, rich diversity, and biocompatibility. This review article emphasizes the last advances and discusses the prospects in the use of polymeric materials as nanocarriers for β-cell imaging and non-invasive drug delivery of insulin and antidiabetic drugs in the management of blood glucose and foot ulcers.

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Section: Sulfonylureas and Glinidesmentioning

confidence: 83%

Section: Biguanidesmentioning

confidence: 99%

Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes

et al. 2023

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“…Particle size, zeta potential and PDI play crucial roles in regulating a variety of processes, including medication absorption, release rate and stability. There have been reports of drug bioavailability and absorption increase at diameters less than 300 nm [ 31 ]. The average diameter of an NAC8 globule was measured as 101 nm as shown in Figure 2 A.…”

Section: Resultsmentioning

confidence: 99%

Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate

Gulshan,

Shah,

Shah

et al. 2023

Pharmaceutics

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Depression is the major mental illness which causes along with loss of interest in daily life, a feeling of hopelessness, appetite or weight changes, anger and irritability. Due to the hepatic first-pass metabolism, the absolute bioavailability of fluvoxamine (FVM) after oral administration is about 50%. By avoiding the pre-systemic metabolism, nasal delivery would boost bioavailability of FVM. Additionally, the absorption is anticipated to occur more quickly than it would via the oral route because of the existence of microvilli and high vasculature. A nonionic surfactant, cholesterol and an arachidonic acid-carboxymethyl chitosan (AA-CMCS) conjugate were used to develop FVM-loaded novasomes. To investigate the effects of surfactant concentration, AA-CMCS conjugate concentration and stirring speed on the novasomes’ characteristics, a Box–Behnken design was used. The dependent variables chosen were zeta potential, polydispersity index and particle size. The AA-CMCS conjugate was confirmed by 1H-NMR and FTIR. Using Design Expert software (version 7; Stat-Ease Inc., Minneapolis, MN, USA), novasomes were further optimized. The chosen optimal formulation (NAC8) was made up of AA-CMCS conjugate, Span 60 and cholesterol. Particle size, zeta potential and PDI values for NAC8 formulation were 101 nm, −35 mV and 0.263, respectively. The NAC8 formulation’s DSC and TGA analysis demonstrated that the medication had been uniformly and amorphously distributed throughout the novasomes. The NAC8 formulation showed 99% and 90% FVM release and permeation, respectively, and the novasome adherence time was 24 h. An improved antidepressant effect along with five-fold increase in bioavailability of FVM was observed after trans-nasal administration of NAC8 formulation compared to the reference commercially available Flumin® tablets. FVM-loaded novasomes administered via the nasal route may therefore constitute an advancement in the management of depression.

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“…Gellan gum/2 percent might be a good option for mending and recovering infarcted cardiac tissue, according to these findings ( Zargar et al, 2019 ). Besides the numerous desirable features of chitosan polymer ( Nomier et al, 2022 ; El-Dakroury et al, 2023 ), it was exploited for MI therapy, forming a chitosan (CH)/dextran (DEX)/β-glycerophosphate (β-GP) parenteral thermo-induced hydrogel occupied with umbilical cord mesenchymal stem cells (UCMSCs). UCMSCs develop towards myocardial and have significant potential for clinical applications of cardiac repair, according to the expression of cardiac markers cTnI and Cx43 and signaling pathways p-Akt and p-ERK1/2 ( Ke et al, 2020 ).…”

Section: Stimuli-responsive Hydrogels For Cardiac Tissue Engineeringmentioning

confidence: 99%

Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering

El-Husseiny

Mady

El-Dakroury

et al. 2023

Front. Bioeng. Biotechnol.

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Biomedicine and tissue regeneration have made significant advancements recently, positively affecting the whole healthcare spectrum. This opened the way for them to develop their applications for revitalizing damaged tissues. Thus, their functionality will be restored. Cardiac tissue engineering (CTE) using curative procedures that combine biomolecules, biomimetic scaffolds, and cells plays a critical part in this path. Stimuli-responsive hydrogels (SRHs) are excellent three-dimensional (3D) biomaterials for tissue engineering (TE) and various biomedical applications. They can mimic the intrinsic tissues’ physicochemical, mechanical, and biological characteristics in a variety of ways. They also provide for 3D setup, adequate aqueous conditions, and the mechanical consistency required for cell development. Furthermore, they function as competent delivery platforms for various biomolecules. Many natural and synthetic polymers were used to fabricate these intelligent platforms with innovative enhanced features and specialized capabilities that are appropriate for CTE applications. In the present review, different strategies employed for CTE were outlined. The light was shed on the limitations of the use of conventional hydrogels in CTE. Moreover, diverse types of SRHs, their characteristics, assembly and exploitation for CTE were discussed. To summarize, recent development in the construction of SRHs increases their potential to operate as intelligent, sophisticated systems in the reconstruction of degenerated cardiac tissues.

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Design, optimization, and in-vivo performance of glipizide-loaded O-carboxymethyl chitosan nanoparticles in insulin resistant/type 2 diabetic rat model

Cited by 13 publications

References 71 publications

Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes

Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes

Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate

Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering

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