Design of therapeutic biomaterials to control inflammation

Tu, Zhaoxu; Zhong, Yiling; Hu, Hanze; Shao, Dan; Haag, Rainer; Schirner, Michael; Lee, Jae Woo; Sullenger, Bruce A.; Leong, Kam W.

doi:10.1038/s41578-022-00426-z

Cited by 244 publications

(191 citation statements)

References 251 publications

(332 reference statements)

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“…Biomaterial-based inflammation control has recently gained much attention in the treatment of arthritis. [24] Biomaterials can be applied to targeted delivery of anti-inflammatory therapeutics to desired cells, tissues, and organs, to anti-inflammatory efficacy, and to reduce toxicity. [24a] Among them, membranecoated nanocarriers inherit the biological functionalities of the source cells, such as superior biocompatibility, long circulation time, and disease-relevant targeting ability; and therefore have been widely used in inflammation-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

et al. 2022

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Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its progression is closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro‐inflammatory M1 macrophages into the anti‐inflammatory M2 phenotype is emerging as a strategy to alleviate OA progression but is compromised by unsatisfactory efficiency. In this study, the reprogramming of mitochondrial dysfunction is pioneered with a camouflaged meta‐Defensome, which can transform M1 synovial macrophages into the M2 phenotype with a high efficiency of 82.3%. The meta‐Defensome recognizes activated macrophages via receptor–ligand interactions and accumulates in the mitochondria through electrostatic attractions. These meta‐Defensomes are macrophage‐membrane‐coated polymeric nanoparticles decorated with dual ligands and co‐loaded with S‐methylisothiourea and MnO2. Meta‐Defensomes are demonstrated to successfully reprogram the mitochondrial metabolism of M1 macrophages by scavenging mitochondrial reactive oxygen species and inhibiting mitochondrial NO synthase, thereby increasing mitochondrial transcription factor A expression and restoring aerobic respiration. Furthermore, meta‐Defensomes are intravenously injected into collagenase‐induced osteoarthritis mice and effectively suppress synovial inflammation and progression of early OA, as evident from the Osteoarthritis Research Society International score. Therefore, reprogramming the mitochondrial metabolism can serve as a novel and practical approach to repolarize M1 synovial macrophages. The camouflaged meta‐Defensomes are a promising therapeutic agent for impeding OA progression in tclinic.

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Section: Introductionmentioning

confidence: 99%

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

et al. 2022

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“…[20,[23][24][25][26][27] Injectable cationic polysaccharide hydrogels are biodegradable and biocompatible and have been clinically approved as dressings for treating trauma. [28][29][30][31][32][33][34][35][36] Based on these observations, we sought to develop a cationic, antibiotic-containing hydrogel that scavenges anionic proinflammatory molecules and bacteria to reduce infection and inflammation following abdominal injury.…”

Section: Introductionmentioning

confidence: 99%

An Injectable Antibiotic Hydrogel that Scavenges Proinflammatory Factors for the Treatment of Severe Abdominal Trauma

Yang

Dawulieti

Zhang

et al. 2022

Adv Funct Materials

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Bacterial infection and excessive inflammation following abdominal injury can cause life-threatening complications that lead to multiple organ failure and death. Removing bacteria and proinflammatory factors-which are predominantly negatively charged-from the wound site with a cationic, antibiotic-containing hydrogel wound dressing is therefore a promising treatment approach for severe abdominal trauma. Here an injectable, self-healing hydrogel composed of the gel-forming glycosaminoglycan oxidized chondroitin sulfate (OCS), cationic polyethylenimine (PEI), and the antibiotic tobramycin (Tob) via a Schiff's base reaction is developed. Compared with hydrogels lacking either PEI or Tob, only the Tob/PEI/OCS hydrogels exhibit a large binding capacity for negatively-charged proinflammatory factors including cell-free DNA, lipopolysaccharides, TNF-α, and high mobility group box 1 protein, and a large reduction in bacterial populations in vitro. In a murine model of severe abdominal trauma, the Tob/PEI/OCS hydrogel exhibits good biodegradability and biosafety, reduced local and systemic inflammation and infection, and prevents multiple organ failure, resulting in 100% survival. This hydrogel dressing is thus a promising biomaterial for preventing complications and improving outcomes following severe abdominal trauma.

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“…There are many studies showing the enhanced biocompatibility effect of polydopamine coat on scaffolds (also on PLGA in bone tissue engineering scaffolds) ( Zhao et al, 2017 ; Yang et al, 2020 ). Materials can also be designed to prevent adhesive interactions of leukocytes and endothelial cells that ameliorate the microenvironment ( Tu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Zhang

Guan

et al. 2022

Front. Bioeng. Biotechnol.

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At present, islet cells transplantation was limited by the way in which islet cells are implanted into the body, their ability to adapt to the microenvironment and the maintenance time for relieving diabetic symptoms. In order to solve this problem, we made PDA-PLGA scaffold loaded with islet cells and used it for skeletal muscle transplantation to investigate its therapeutic effect in the treatment of diabetes. The PLGA scaffold was prepared by the electrospinning method, and modified by polydopamine coating. A rat diabetic model was established to evaluate the efficacy of PDA-PLGA scaffold loaded with RINm5f islet cells through skeletal muscle transplantation. The results showed that the PDA-PLGA scaffold has good biosafety performance. At the same time, transplantation of the stent to the skeletal muscle site had little effect on the serum biochemical indicators of rats, which was conducive to angiogenesis. The PDA-PLGA scaffold had no effect on the secretory function of pancreatic islet cells. The PDA-PLGA scaffold carrying RINm5f cells was transplanted into the skeletal muscle of type I diabetic rats. 1 week after the transplantation of the PDA-PLGA cell scaffold complex, the blood glucose of the treatment group was significantly lower than that of the model group (p < 0.001) and lasted for approximately 3 weeks, which further indicated the skeletal muscle transplantation site was a new choice for islet cell transplantation in the future.

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Design of therapeutic biomaterials to control inflammation

Cited by 244 publications

References 251 publications

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

An Injectable Antibiotic Hydrogel that Scavenges Proinflammatory Factors for the Treatment of Severe Abdominal Trauma

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

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