Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Zhang, Meishuang; Du, Hongwei; Guan, Yueqi; Liu, Jingyue; Wang, Su-Shan; Li, Haoran; Zhang, Wenyou; Han, Hao; Zhang, Ming; Chen, Li

doi:10.3389/fbioe.2022.927348

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…PLGA-PDA scaffolds were also applied to cell carriers. Zhang et al [ 85 ] prepared a PLGA scaffold via the electrospinning method and modified it with a polydopamine coating. The PDA-PLGA scaffold promoted angiogenesis and it exhibited a good biological safety performance.…”

Section: Plga Scaffold Surface-modified Materialsmentioning

confidence: 99%

Surface Modification Progress for PLGA-Based Cell Scaffolds

Yan,

Hua,

Wang

et al. 2024

Polymers

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Poly(lactic-glycolic acid) (PLGA) is a biocompatible bio-scaffold material, but its own hydrophobic and electrically neutral surface limits its application as a cell scaffold. Polymer materials, mimics ECM materials, and organic material have often been used as coating materials for PLGA cell scaffolds to improve the poor cell adhesion of PLGA and enhance tissue adaptation. These coating materials can be modified on the PLGA surface via simple physical or chemical methods, and coating multiple materials can simultaneously confer different functions to the PLGA scaffold; not only does this ensure stronger cell adhesion but it also modulates cell behavior and function. This approach to coating could facilitate the production of more PLGA-based cell scaffolds. This review focuses on the PLGA surface-modified materials, methods, and applications, and will provide guidance for PLGA surface modification.

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Section: Plga Scaffold Surface-modified Materialsmentioning

confidence: 99%

Surface Modification Progress for PLGA-Based Cell Scaffolds

Yan,

Hua,

Wang

et al. 2024

Polymers

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show abstract

“…In addition to the two aforementioned research hotspots of transplant sites, studies on transplanting islets into the intrapleural (135), skeletal muscle (136), anterior chamber of the eye (ACE) (137), and other sites have been reported (138)(139)(140). However, research on these aspects is still in its infancy, and there is a large gap in clinical applications.…”

Section: Optimal Transplant Sitementioning

confidence: 99%

Pancreatic islet transplantation: current advances and challenges

Wang,

Huang,

Liu

et al. 2024

Front. Immunol.

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Diabetes is a prevalent chronic disease that traditionally requires severe reliance on medication for treatment. Oral medication and exogenous insulin can only temporarily maintain blood glucose levels and do not cure the disease. Most patients need life-long injections of exogenous insulin. In recent years, advances in islet transplantation have significantly advanced the treatment of diabetes, allowing patients to discontinue exogenous insulin and avoid complications.Long-term follow-up results from recent reports on islet transplantation suggest that they provide significant therapeutic benefit although patients still require immunotherapy, suggesting the importance of future transplantation strategies. Although organ shortage remains the primary obstacle for the development of islet transplantation, new sources of islet cells, such as stem cells and porcine islet cells, have been proposed, and are gradually being incorporated into clinical research. Further research on new transplantation sites, such as the subcutaneous space and mesenteric fat, may eventually replace the traditional portal vein intra-islet cell infusion. Additionally, the immunological rejection reaction in islet transplantation will be resolved through the combined application of immunosuppressant agents, islet encapsulation technology, and the most promising mesenchymal stem cells/regulatory T cell and islet cell combined transplantation cell therapy. This review summarizes the progress achieved in islet transplantation, and discusses the research progress and potential solutions to the challenges faced.

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“…Many of them have been approved for commercial applications, including poly(glycolic acid) (PGA), poly(lactic acid) (PLA), and poly(lactic-co-glycolic acid) (PLGA), etc., ( Alvarez-Mendez et al, 2023 ). The significant drawback lies in inducing foreign body reactions to the host and insufficient angiogenesis ( Zhang et al, 2022 ).…”

Section: Biomaterialsmentioning

confidence: 99%

Research progress of biomaterials and innovative technologies in urinary tissue engineering

Duan

Wang

Fan

et al. 2023

Front. Bioeng. Biotechnol.

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Substantial interests have been attracted to multiple bioactive and biomimetic biomaterials in recent decades because of their ability in presenting a structural and functional reconstruction of urinary tissues. Some innovative technologies have also been surging in urinary tissue engineering and urological regeneration by providing insights into the physiological behavior of the urinary system. As such, the hierarchical structure and tissue function of the bladder, urethra, and ureter can be reproduced similarly to the native urinary tissues. This review aims to summarize recent advances in functional biomaterials and biomimetic technologies toward urological reconstruction. Various nanofirous biomaterials derived from decellularized natural tissues, synthetic biopolymers, and hybrid scaffolds were developed with desired microstructure, surface chemistry, and mechanical properties. Some growth factors, drugs, as well as inorganic nanomaterials were also utilized to enhance the biological activity and functionality of scaffolds. Notably, it is emphasized that advanced approaches, such as 3D (bio) printing and organoids, have also been developed to facilitate structural and functional regeneration of the urological system. So in this review, we discussed the fabrication strategies, physiochemical properties, and biofunctional modification of regenerative biomaterials and their potential clinical application of fast-evolving technologies. In addition, future prospective and commercial products are further proposed and discussed.

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Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Cited by 5 publications

References 39 publications

Surface Modification Progress for PLGA-Based Cell Scaffolds

Surface Modification Progress for PLGA-Based Cell Scaffolds

Pancreatic islet transplantation: current advances and challenges

Research progress of biomaterials and innovative technologies in urinary tissue engineering

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