Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Yang, Haitao; Li, Jing; Patel, Sravan Kumar; Palmer, Kenneth E.; Devlin, Bríd; Rohan, Lisa C.

doi:10.3390/pharmaceutics11040184

Cited by 78 publications

(61 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, results of in this study indicate that release of CVL from NPs is not predominantly driven by a solo mechanism, but a combined mechanism of Fickian and non-Fickian release. When the literature is examined, similar results are found [42].…”

Section: Release Kinetics Studysupporting

confidence: 62%

Evaluation of carvedilol-loaded Eudragit® nanoparticles

Güven¹,

Öztürk²,

Yenilmez³

2020

jrp

View full text Add to dashboard Cite

The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulation by spray dryer technique and was to examine the effect of different derivative of Eudragit ® polymers on entrapment efficiency (EE%), dissolution profile and release kinetics. Two nonbiodegradable positively charged polymers, Eudragit ® RS100 and RL100 were used alone or in combination. The prepared formulations were evaluated for their particle size, polydispersity index, zeta potential, in vitro dissolution and in vitro release kinetics study. Particle sizes of placebo nanoparticles and carvedilol loaded nanoparticles were 418.2±18.5/ 402.3±22.0/ 416.3±12.5 and 535.5±13.8/ 529.4±10.2/ 530.4±10.4 nm, respectively with PDI values of approximately 0.4-0.6 for each. Carvedilol loading was resulted in positive electrical charge on nanoparticles. The drug encapsulation efficiency was 68.45±4.67/ 63.58±2.30/ 65.67±4.21. In vitro cumulative release from the nanoparticles was 80-90 % at 48 hour. Morphology and solid state analyzes were performed also in nanoparticles. The results of this research indicate that spray dryer technique is suitable for carvedilol loaded Eudragit ® nanoparticles and no burst effect but a prolonged drug release was observed from formulations.

show abstract

Section: Release Kinetics Studysupporting

confidence: 62%

Evaluation of carvedilol-loaded Eudragit® nanoparticles

Güven¹,

Öztürk²,

Yenilmez³

2020

jrp

View full text Add to dashboard Cite

show abstract

“…PLGA NPs can be formulated by use of emulsion evaporation, emulsion diffusion, solvent displacement and nanoprecipitation techniques. Figure 2 shows the use of a double emulsion-solvent evaporation technique in the formulation of a PLGA based co-delivery platform [31]. Poly(lactic acid-co-glycolic acid) (PLGA) is a polyester, copolymer block made up of polyglycolic acid and poly-lactic acid [28].…”

Section: Plgamentioning

confidence: 99%

“…PLGA NPs can be formulated by use of emulsion evaporation, emulsion diffusion, solvent displacement and nanoprecipitation techniques. Figure 2 shows the use of a double emulsion-solvent evaporation technique in the formulation of a PLGA based co-delivery platform [31]. In 2017, Yan-na Cui et al formulated paclitaxel (PTX)-loaded magnetic PLGA (50:50) NPs, surface modified with transferrin (TF).…”

Section: Plgamentioning

confidence: 99%

See 1 more Smart Citation

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

View full text Add to dashboard Cite

Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

show abstract

“…This highlights the need to develop prevention systems that women can initiate without their partner's consent [2]. In this scenario, topical preexposure prophylaxis (PrEP) with antiretroviral drugs is one option to prevent the sexual transmission of HIV, since they can be applied in the vagina and serve as a method of protection that can be controlled by women themselves, thus empowering them in the fight against HIV-1 infection without the consent of their sexual partner [3].…”

Section: Introductionmentioning

confidence: 99%

Vaginal Polyelectrolyte Layer-by-Layer Films Based on Chitosan Derivatives and Eudragit® S100 for pH Responsive Release of Tenofovir

et al. 2020

View full text Add to dashboard Cite

Women are still at high risk of contracting the human immunodeficiency virus (HIV) virus due to the lack of protection methods under their control, especially in sub-Saharan countries. Polyelectrolyte multilayer smart vaginal films based on chitosan derivatives (chitosan lactate, chitosan tartate, and chitosan citrate) and Eudragit® S100 were developed for the pH-sensitive release of Tenofovir. Films were characterized through texture analysis and scanning electron microscopy (SEM). Swelling and drug release studies were carried out in simulated vaginal fluid and a mixture of simulated vaginal and seminal fluids. Ex vivo mucoadhesion was evaluated in bovine vaginal mucosa. SEM micrographs revealed the formation of multilayer films. According to texture analysis, chitosan citrate was the most flexible compared to chitosan tartrate and lactate. The swelling studies showed a moderate water uptake (<300% in all cases), leading to the sustained release of Tenofovir in simulated vaginal fluid (up to 120 h), which was accelerated in the simulated fluid mixture (4–6 h). The films had high mucoadhesion in bovine vaginal mucosa. The multilayer films formed by a mixture of chitosan citrate and Eudragit® S100 proved to be the most promising, with zero toxicity, excellent mechanical properties, moderate swelling (<100%), high mucoadhesion capacity, and Tenofovir release of 120 h and 4 h in vaginal fluid and the simulated fluid mixture respectively.

show abstract

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Cited by 78 publications

References 68 publications

Evaluation of carvedilol-loaded Eudragit® nanoparticles

Evaluation of carvedilol-loaded Eudragit® nanoparticles

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Vaginal Polyelectrolyte Layer-by-Layer Films Based on Chitosan Derivatives and Eudragit® S100 for pH Responsive Release of Tenofovir

Contact Info

Product

Resources

About