Design of nanomaterial based systems for novel vaccine development

Liu, Yang; Li, Wen; Kirberger, Michael; Liao, Wenzhen; Ren, Jiaoyan

doi:10.1039/c5bm00507h

Cited by 58 publications

(40 citation statements)

References 135 publications

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“…One promising area that is rapidly gaining attention is the use of nanotechnology in vaccine development (Yang et al, 2016;Zhao et al, 2008), which is considered one of the most effective strategies to conquer the low immunogenicity of epitope-based vaccines. Nanovaccines are new classes of vaccines that have been developed by incorporating epitopes into nanoparticles, which are microscopic particles with at least one dimension between 1 and 100 nm in size and a very high surface area to volume ratio (Horikoshi and Serpone, 2013;Srirajaskanthan and Preedy, 2011).…”

Section: Epitope-based Subunit Vaccinesmentioning

confidence: 99%

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Negahdaripour

Golkar

Hajighahramani

et al. 2017

Biotechnology Advances

104

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Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility. They also resemble pathogens in terms of their size. Their multivalency allows an orderly repetitive display of antigens on their surface, which induces a stronger immune response than single immunogens. In vaccine design, SAPN self-adjuvanticity is regarded an outstanding advantage, since the use of toxic adjuvants is no longer required. SAPNs are usually composed of helical or β-sheet secondary structures and are tailored from natural peptides or de novo structures. Flexibility in subunit selection opens the door to a wide variety of molecules with different characteristics. SAPN engineering is an emerging area, and more novel structures are expected to be generated in the future, particularly with the rapid progress in related computational tools. The aim of this review is to provide a state-of-the-art overview of self-assembled peptide nanoparticles and their use in vaccine design in recent studies. Additionally, principles for their design and the application of computational approaches to vaccine design are summarized.

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Section: Epitope-based Subunit Vaccinesmentioning

confidence: 99%

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Negahdaripour

Golkar

Hajighahramani

et al. 2017

Biotechnology Advances

104

View full text Add to dashboard Cite

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“…These strategies include the use of biological agents such as RNA interference and microRNA mimetics to down-regulate the expression of ABC family members (Shen et al, 2013; Kasinathan et al, 2014; Guo et al, 2015), development of new drug delivery systems that can bypass the ABC family of transporters such as nanoparticles (Callaghan et al, 2014; Lee et al, 2014; Singh et al, 2015; Bar-Zeev et al, 2016; Yang et al, 2016), development of new chemotherapeutic agents that are not substrate to ABC transporters (Su et al, 2012) and the use of ultrasound waves (Wu et al, 2011) ( Figure 3 ).…”

Section: Non-traditional Strategies To Overcome Effects Of Abc Transpmentioning

confidence: 99%

The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy

Saleh²,

et al. 2017

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Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. “Resistance to chemotherapy,” however, is a comprehensive phrase that refers to a variety of different mechanisms in which ATP-binding cassette (ABC) mediated efflux dominates. The ABC is one of the largest gene superfamily of transporters among both eukaryotes and prokaryotes; it represents a variety of genes that code for proteins, which perform countless functions, including drug efflux – a natural process that protects cells from foreign chemicals. Up to date, chemotherapy failure due to ABC drug efflux is an active research topic that continuously provides further evidence on multiple drug resistance (MDR), aiding scientists in tackling and overcoming this issue. This review focuses on drug resistance by ABC efflux transporters in human, viral, parasitic, fungal and bacterial cells and highlights the importance of the MDR permeability glycoprotein being the mutual ABC transporter among all studied organisms. Current developments and future directions to overcome this problem are also discussed.

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“…The preparation methods of nanoparticle composite carrier include the physical and chemical methods [10], the following paragraphs describe the construction and related immune function of several inorganic nanocomposites.…”

Section: Construction and Immunological Evaluation Of Inorganic Nanocmentioning

confidence: 99%

Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential

Zhong¹,

Zhuang²

2017

J Infect Dis Ther

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For a long time, the most important means of controlling infectious diseases is prevention, and vaccination is considered the most effective measures, so the preparation and improvement of the vaccine is not only supported by the medical profession, it is the concern of the broad masses of the people. A number of biomolecules have been used as antigens to construct novel vaccine preparations, including Virus-like particles (VLPs) or bacteria, dendritic cells, nucleic acids and peptides. Immunostimulatory nanocomposites are based on the above molecules as vectors, encapsulating immune adjuvants, and nanoparticles for the construction of novel vaccines. Compared to traditional vaccines, adjuvants, nanoparticles alone, the efficacy of immunostimulatory nanocomposites as potential vaccines shows increased CD4 + , CD8+ T cell count, secretion of cytokine interferon-gamma and IL-4 functions also significantly enhanced, in addition, the use of nanoparticles enhances the Immune irritation of adjuvants, VLPs and other molecules on humoral and cellular immune responses. Thus, immunostimulatory nanocomposites may be potential vaccines for future prevention and treatment applications.

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Design of nanomaterial based systems for novel vaccine development

Cited by 58 publications

References 135 publications

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

Harnessing self-assembled peptide nanoparticles in epitope vaccine design

The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy

Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential

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